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4D ultrasound has the potential to provide complex temporal information needed for the proper diagnosis of cardiac pathologies. The objective of this study is to demonstrate a potential pipeline for the clinical evaluation of 4D cardiac strain using only 4D (RT3D) ultrasound data. First, 4D cardiac ultrasound data is collected using a Siemens SC2000 Ultrasound machine. Then, the raw Rho-Theta data...
Most current elastography methods remain qualitative or display only strain information due to the inexact internal stress distribution. A more accurate result may be obtained by employing force sensors to gauge the applied vertical compression force on skin surface through the ultrasound transducer. A computationally efficient superposition algorithm based on Love's closed-form equation (SLE) is...
Delivery of therapeutic compounds to the brain is limited, because due to their molecular size they cannot cross the blood-brain barrier (BBB). Focused ultrasound (FUS) after administration of microbubbles into the blood-stream has been shown to open the BBB locally, non-invasively and reversibly. In this study, we investigated the time required for BBB's permeability at the sonicated region to revert...
Harmonic Motion Imaging (HMI) is a technique capable of imaging tissue mechanical properties during acoustic radiation force application. Recently, HMIFU has been shown capable for high-intensity focused ultrasound (HIFU) therapy and monitoring. Here, a theoretical analysis of the Harmonic Motion Imaging for Focused Ultrasound (HMIFU) system is performed using a 2D nonlinear wave propagation model...
Sounds generated by turbulent blood flow through partially occluded brachial artery were used to model sounds expected from coronary occlusions. Two methods of nonlinear analysis, third-order autocovariance and time reversal, were evaluated for their ability to detect blood flow turbulence. The values obtained from turbulent acoustic data were compared against surrogate data having similar power spectra...
Medial tibial stress syndrome (MTSS) is pain or discomfort in the leg from repetitive running on hard surfaces or forcible excessive use of foot flexors. Early diagnosis is extremely critical for proper treatment and reduces complications. Quantitative ultrasound (QUS) has been widely used to assess bone quality non-invasively, it is also radiation free, repeatable, safe, relatively accurate, and...
Coronary artery disease (CAD), a leading cause of death in the United States, has few early diagnostic mechanisms. Acoustic detection of sound associated with turbulent blood flow in coronary arteries has been shown to discriminate normal and abnormal subjects; however, improved performance is required for clinical use. Nonlinear analysis methods sensitive to turbulence could improve acoustic detection...
The exact mechanism behind the blood-brain barrier (BBB) opening using Focused Ultrasound (FUS) and microbubbles remains unknown. Here, the effects of the murine skull on the pressure threshold of inertial cavitation were investigated using a passive cavitation detector (PCD) in conjunction with B-mode imaging. A cylindrical vessel with a 610-??m diameter inside a polyacrylamide gel was generated...
The following topics are dealt with: biosensor; data analysis; biologic scaffold; finite element model; magnetic resonance prostate imaging; breast cancer;optical tomography; osteocytes; computational fluid dynamics; ultrasound elastography.
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