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Energy metabolism rates have been hypothesized to reflect abnormalities in diseases such as heart failure and diabetes. Using magnetic resonance imaging (MRI) technology, these rates can be imaged in multiple locations in the body. Due to similarities in muscle striations between myocardial and skeletal tissues, the metabolism of these substances will be imaged in the leg in order to increase patient...
Vascular endothelial growth factor (VEGF) has been shown to increase the adhesion of human breast cancer cells to human brain endothelium [1]. However, how VEGF accomplishes this is not well understood. We hypothesize that VEGF compromises the integrity of brain microvascular endothelium is one mechanism to increase the tumor cell adhesion. To test our hypothesis, using a Transwell system, we measured...
Severe hemorrhage occurs in up to 7% of all vacuum assisted breast biopsy procedures. The current standard of practice to stop hemorrhage is the use of external pressure to the breast. While this can control minimal bleeding it is not localized enough to stop serious bleeding. If bleeding cannot be controlled through exterior pressure the only treatment is to perform surgery on the patient which is...
System design, performance characteristics and representative clinical findings are described for a second generation dynamic near-infrared optical tomography breast imager that examines both breasts simultaneously under conditions of rest and controlled provocation. Novel elements of the system include incorporation of high-density optical sensing heads (8192 channels) that include feedback-controlled...
We present the results of a study in which we monitored anti-angiogenic therapy response in a mouse cancer model with in-vivo dynamic fluorescence imaging. In the experiments indocyanine green (ICG) was used as a fluorescent optical contrast agent and its time-dependent uptake and washout before and after the administration of bevacizumab was recorded. We found that compared with other organs, tumors...
The state of the art Magnetic Resonance Imaging (MRI) coil for Prostate imaging is the endorectal coil. The endorectal coil is uncomfortable for patients and distorts the prostate during imaging. This paper investigates the use of an external coil in the Helmholtz configuration to image the prostate and pelvic region.
Surface roughness due to micro and nanostructures of butterfly wings create hydrophobic surfaces. In this study, two different experimental techniques were used to characterize the effect of structural features on hydrophobicity of wings. The static and dynamic (advancing and receding) contact angle studies, and Atomic force microscopy (AFM) and optical profilometry characterization were conducted...
Diffuse optical imaging of the peripheral vascular reactivity is implemented at the major arteries of the foot. Transmitted light intensities are recorded in response to vascular occlusions induced by pressure cuffs. These dynamic measurements promise to help identify various peripheral vascular diseases.
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