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Epithelial-stromal interactions play a crucial role in normal embryonic development and carcinogenesis of the human breast while the underlying mechanisms of these events remain poorly understood. Here, we constructed a physiologically relevant, 3D culture surrogate of complex human breast tissue that included a tri-culture system made up of human mammary epithelial cells (MCF10A), fibroblasts and...
Embryonic stem cells (ESCs) hold promise either as an in vitro model recapitulating early embryonic development or as a renewable source of therapeutically useful cells. However, 2D culture system, which is still generally utilized in ESCs differentiation strategies, has greatly impeded our learning more information about ESCs proliferation/differentiation in situ. Here, a high aspect ratio vessel...
Tissue engineering within three-dimensional scaffolds represents a developing field with the potential to create in vitro livers. Human liver cells, HepG2, respond to cues in their immediate microenvironment by modulating cell functions including cell proliferation, urea synthesis and drug metabolism. The importance of three-dimensional environments draws from the fact that it has been extensively...
The pluripotency of human embryonic stem cells (hESCs) provides the unique opportunity to derive tissue specific cells, an ability of particular interest in regenerative medicine. In the study of bone regeneration, there is interest in directing hESCs to mesenchymal stem cells (MSCs), which under the appropriate conditions gives rise to mineral-producing osteoblasts. To evaluate the efficiency of...
Rotator cuff tears often occur at the tendon-bone insertion site, a fibrocartilaginous interface that is not regenerated during current repairs. Our aim is to regenerate the insertion site through use of extracellular matrix based scaffolds. In this study, we evaluated the response of mineralized and non-mineralized nanofiber scaffolds to cell culture environment without the influence of cell growth...
Spinal cord injury (SCI) affects thousands of Americans each year. The injury results in local cell loss in the spinal cord, interrupting the connections between brain and periphery. Current treatment options for SCI are limited due to the inability of adult neurons to regenerate in the inhibitory environment of the injured central nervous system (CNS). The primary goal of this work is to design a...
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