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Tissue engineering within three-dimensional scaffolds represents a developing field with the potential to create in vitro livers. Human liver cells, HepG2, respond to cues in their immediate microenvironment by modulating cell functions including cell proliferation, urea synthesis and drug metabolism. The importance of three-dimensional environments draws from the fact that it has been extensively...
We present the results of a study in which we monitored anti-angiogenic therapy response in a mouse cancer model with in-vivo dynamic fluorescence imaging. In the experiments indocyanine green (ICG) was used as a fluorescent optical contrast agent and its time-dependent uptake and washout before and after the administration of bevacizumab was recorded. We found that compared with other organs, tumors...
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