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CD151 plays an important role in the regulation of cell migration, vascular morphogenesis, and cancer metastasis. Many of these processes are related to the strength of cell-matrix attachment. In this study, traction force microscopy (TFM) was used to determine whether knockdown of CD151 in endothelial cells would lead to a significant modification in cell-matrix adhesion. Human dermal microvascular...
Rotator cuff tears are among the most common shoulder injuries that require surgery. High failure rates of biological graft-based repairs underscore the need for functional alternatives. In this study, effects of nanofiber organization on adhesion of cuff fibroblasts (hRCF) and human mesenchymal stem cells (hMSC) are evaluated. It is hypothesized that fiber alignment will regulate cell morphology...
The primary cilium, a hair-like projection from the cellular membrane, is involved in fluid flow sensing. In this study, the primary cilium is modeled as a thin beam undergoing large deflection due to fluid drag forces. For the first time, the bending response is analyzed with a model combining large angle rotations with the assumption of a linear drag force along the ciliary length. The model is...
Osteocytes exhibit solid-like viscoelastic behavior in response to mechanical stresses. The goal of this study was to determine the viscoelastic properties of osteocytes using a combined finite element analysis (FE) modeling and experimental approach. The three-dimensional (3D) cell shape of the osteocyte under fluid flow was reconstructed using using a novel pseudo-3D microscopy technique. The cell...
The research material presented in this paper is a continuation of work done in analyzing impact properties of a biomaterial found in a banana peel. Important energy absorbing characteristics, e.g., plateau stress, locking stress, deformation mode and crushing progression, collapsing mechanism, and crushing stroke of the foam filled (peel) structure are compared with the previously analyzed unfilled...
The endothelial glycocalyx (GCX) mediates flow-induced nitric oxide release via heparan sulfate (HS), but the GCX structure is unclear and the specific HS core protein(s) involved in this mechanotransduction is unknown. Our study tests the hypotheses that flow regulates GCX thickness and organization and that the HS glypican-1 core protein mediates flow-induced activation of endothelial nitric oxide...
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