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Macromolecular transport across the vessel wall, apparently the earliest pre-atherosclerotic event, is known to occur due to advection by transmural pressure driven water transport, characterized by the hydraulic conductivity (Lp). Our group's discovery of the presence of aquaporin-1 (AQP) in aortic endothelial cells suggests a new possibility of water transport across the endothelial cell (EC), alongside...
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes mellitus, and despite many years of research it continues to be the major cause of blindness in adults. Understanding the molecular mechanisms by which transport across the inner Blood Retinal Barrier (iBRB) is regulated is a key step for the discovery of improved means to control vascular permeability and loss of...
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