The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
In breast cancer treatment for many cases intrinsic or acquired resistance against available therapeutics leads to death. According to the present biological understanding, drug resistance is caused by molecular mechanisms in the complex network of proteins that regulate cell proliferation by activation of the estrogen receptor (ER), hereby allowing the cell to bypass the classical estrogen receptor...
In breast cancer treatment for many cases intrinsic or acquired resistance against available therapeutics leads to death. According to the present biological understanding, drug resistance is caused by molecular mechanisms in the complex network of proteins that regulate cell proliferation by activation of the estrogen receptor (ER), hereby allowing the cell to bypass the classical estrogen receptor...
Intensity modulated radiation therapy (IMRT) is often used for the treatment of soft tissue sarcoma. Due to high radiation doses, many patients have high risk of suffering from a femoral bone fracture sometime following the IMRT treatment. The most common type of radiation treatment-related fracture is a stress fracture. The fracture risk rate may be as high as 24% in sarcoma patients who have undergone...
Intensity modulated radiation therapy (IMRT) is often used for the treatment of soft tissue sarcoma. Due to high radiation doses, many patients have high risk of suffering from a femoral bone fracture sometime following the IMRT treatment. The most common type of radiation treatment-related fracture is a stress fracture. The fracture risk rate may be as high as 24% in sarcoma patients who have undergone...
In this paper, we build a mathematical model of the whole-body neuromuscular network and identify its parameters by optical motion capture, inverse dynamics computation, and statistical analysis. The model includes a skeleton, a musculotendon network, and a neuromuscular network. The skeleton is composed of 155 joints representing the inertial property and mobility of the human body. The musculotendon...
In this paper, we build a mathematical model of the whole-body neuromuscular network and identify its parameters by optical motion capture, inverse dynamics computation, and statistical analysis. The model includes a skeleton, a musculotendon network, and a neuromuscular network. The skeleton is composed of 155 joints representing the inertial property and mobility of the human body. The musculotendon...
The molecular circadian clock which is present in almost all cells of animal organisms exerts a control on the cell division cycle in proliferating tissues by modulating the activity of cyclins and cyclin dependent kinases (CDKs), the proteins which determine transitions from one phase of the cell cycle to the following one, until effective division. Each peripheral cell circadian clock is under the...
The molecular circadian clock which is present in almost all cells of animal organisms exerts a control on the cell division cycle in proliferating tissues by modulating the activity of cyclins and cyclin dependent kinases (CDKs), the proteins which determine transitions from one phase of the cell cycle to the following one, until effective division. Each peripheral cell circadian clock is under the...
Transcutaneous (surface) electrical stimulation (TES) is a widely applied technique for muscle atrophy treatment, muscle force training, endurance training, pain treatment, functional movement therapy, and the restoration of motor functions. We present a new TES technology based on a multi-channel stimulation approach, which allows us to perform real-time spatial and temporal variations of the electrical...
Transcutaneous (surface) electrical stimulation (TES) is a widely applied technique for muscle atrophy treatment, muscle force training, endurance training, pain treatment, functional movement therapy, and the restoration of motor functions. We present a new TES technology based on a multi-channel stimulation approach, which allows us to perform real-time spatial and temporal variations of the electrical...
Saving life of patients with acute life-threatening heart failure is a major challenge. One has to correct several fatal hemodynamic abnormalities at the same time within a limited time frame. The formulation of such complicated treatments enables the development of a system that can be used to save automatically lives of patients with acute heart failure, an autopilot system. To accomplish this,...
Saving life of patients with acute life-threatening heart failure is a major challenge. One has to correct several fatal hemodynamic abnormalities at the same time within a limited time frame. The formulation of such complicated treatments enables the development of a system that can be used to save automatically lives of patients with acute heart failure, an autopilot system. To accomplish this,...
We update a cardiopulmonary (CP) model previously developed by our group, more convincingly validate the model with additional hemodynamic and echocardiographic data, and demonstrate the utility of the model by extending it to the simulation of left ventricular diastolic dysfunction (LVDD) via a simple parameter change. The model has considerable potential for the characterization of complex cardiopulmonary...
We update a cardiopulmonary (CP) model previously developed by our group, more convincingly validate the model with additional hemodynamic and echocardiographic data, and demonstrate the utility of the model by extending it to the simulation of left ventricular diastolic dysfunction (LVDD) via a simple parameter change. The model has considerable potential for the characterization of complex cardiopulmonary...
Bayesian Networks provide a flexible way of incorporating different types of information into a single probabilistic model. In a medical setting, one can use these networks to create a patient model that incorporates lab test results, clinician observations, vital signs, and other forms of patient data. In this paper, we explore a simple Bayesian Network model of the cardiovascular system and evaluate...
Bayesian Networks provide a flexible way of incorporating different types of information into a single probabilistic model. In a medical setting, one can use these networks to create a patient model that incorporates lab test results, clinician observations, vital signs, and other forms of patient data. In this paper, we explore a simple Bayesian Network model of the cardiovascular system and evaluate...
Previously, we built a pulmonary and cardiovascular integrated model which is driven by O2 consumption. However this model is adjusted to average person and cannot correspond to individual difference. It needs parameter adjustment to be applied for simulation of a particular person. We used lumped parameter models, which have simple structures and are well suited to macro-model. However they have...
Previously, we built a pulmonary and cardiovascular integrated model which is driven by O2 consumption. However this model is adjusted to average person and cannot correspond to individual difference. It needs parameter adjustment to be applied for simulation of a particular person. We used lumped parameter models, which have simple structures and are well suited to macro-model. However they have...
This paper presents a real-time digital simulator (DRTS) for possible use in testing of medical devices. The simulator runs a model of a physiological system (an organ or a group of organs) in real time and uses A/D and D/A cards to interface the simulation results to real medical equipment. With this simulator, the tests can be made as thorough as needed without much increase in cost
This paper presents a real-time digital simulator (DRTS) for possible use in testing of medical devices. The simulator runs a model of a physiological system (an organ or a group of organs) in real time and uses A/D and D/A cards to interface the simulation results to real medical equipment. With this simulator, the tests can be made as thorough as needed without much increase in cost
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.