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Previously, we introduced a new harmonic motion imaging (HMI) technique for simultaneous monitoring and generation of ultrasound therapy treatment using a single element focused-ultrasound and one pulse-echo transducer. The new HMI technique uses an amplitude-modulated beam (instead of using two beams) that has a stable focal zone for the applied harmonic radiation force. The harmonic radiation force...
Previously, we introduced a new harmonic motion imaging (HMI) technique for simultaneous monitoring and generation of ultrasound therapy treatment using a single element focused-ultrasound and one pulse-echo transducer. The new HMI technique uses an amplitude-modulated beam (instead of using two beams) that has a stable focal zone for the applied harmonic radiation force. The harmonic radiation force...
The role and the potentialities of high-resolution infrared thermography, combined to bio-heat modelling, have been largely described in the last years in a wide variety of biomedical applications. Quantitative assessment over time of the cutaneous temperature and/or of other biomedical parameters related to the temperature (e.g., cutaneous blood flow, thermal inertia, sympathetic skin response) allows...
The role and the potentialities of high-resolution infrared thermography, combined to bio-heat modelling, have been largely described in the last years in a wide variety of biomedical applications. Quantitative assessment over time of the cutaneous temperature and/or of other biomedical parameters related to the temperature (e.g., cutaneous blood flow, thermal inertia, sympathetic skin response) allows...
Concerns have been expressed about safety of MRI examination of two groups of people, namely pregnant mothers and cardiac pacemaker bearers. The main uncertainty relates to excessive heating by pulsed radio frequency (RF) fields. To address these issues, numerical evaluations of the power deposition are performed for a 27-week old fetus in a simplified model of the mother, and a realistic model of...
Concerns have been expressed about safety of MRI examination of two groups of people, namely pregnant mothers and cardiac pacemaker bearers. The main uncertainty relates to excessive heating by pulsed radio frequency (RF) fields. To address these issues, numerical evaluations of the power deposition are performed for a 27-week old fetus in a simplified model of the mother, and a realistic model of...
A 3-dimensional hemispheric computational brain model is developed to simulate infusion of cold saline in the carotid arteries in terms of brain cooling for stroke therapy. The model is based on the Pennes bioheat equation, with four tissue layers: white matter, gray matter, skull, and scalp. The stroke lesion is simulated by reducing blood flow to a selected volume of the brain by a factor of one-third,...
A 3-dimensional hemispheric computational brain model is developed to simulate infusion of cold saline in the carotid arteries in terms of brain cooling for stroke therapy. The model is based on the Pennes bioheat equation, with four tissue layers: white matter, gray matter, skull, and scalp. The stroke lesion is simulated by reducing blood flow to a selected volume of the brain by a factor of one-third,...
This paper deals with the prediction of body core temperature during physical activity in different environmental conditions using first-principles models and data-driven models. We argue that prediction of physiological variables through other correlated physiological variables using data-driven techniques is an ill-posed problem. To make predictions produced by data-driven models accurate and stable...
This paper deals with the prediction of body core temperature during physical activity in different environmental conditions using first-principles models and data-driven models. We argue that prediction of physiological variables through other correlated physiological variables using data-driven techniques is an ill-posed problem. To make predictions produced by data-driven models accurate and stable...
To study calcium mediated arrhythmogenesis, we have developed a multi-modal optical mapping system that is able to perform dual calcium voltage and ratiometric calcium optical mapping in the same cardiac preparation. To ensure physiological stability of the preparation, the ECG, coronary pressure, coronary flow, and perfusion temperature are continuously monitored throughout each experiment. The multi-modal...
To study calcium mediated arrhythmogenesis, we have developed a multi-modal optical mapping system that is able to perform dual calcium voltage and ratiometric calcium optical mapping in the same cardiac preparation. To ensure physiological stability of the preparation, the ECG, coronary pressure, coronary flow, and perfusion temperature are continuously monitored throughout each experiment. The multi-modal...
Radio frequency (RF) tumor ablation has become an accepted treatment modality for tumors not amenable to surgery. The need for larger ablation zones has required increase in RF generator power, with current generation devices delivering 200-250 W. Skin burns due to ground pad heating have become a common complication and are now a limiting factor for further increase in ablation zone and generator...
Radio frequency (RF) tumor ablation has become an accepted treatment modality for tumors not amenable to surgery. The need for larger ablation zones has required increase in RF generator power, with current generation devices delivering 200-250 W. Skin burns due to ground pad heating have become a common complication and are now a limiting factor for further increase in ablation zone and generator...
Fast processes in cardiac electrophysiology are often studied at temperatures lower than physiological. Extrapolation of values is based on widely accepted Q10 (Arrhenius) model of temperature dependence (ratio of kinetic properties for a 10degC change in temperature). In this study, we set out to quantify the temperature dependence of essential parameters that define spatiotemporal behavior of cardiac...
Fast processes in cardiac electrophysiology are often studied at temperatures lower than physiological. Extrapolation of values is based on widely accepted Q10 (Arrhenius) model of temperature dependence (ratio of kinetic properties for a 10degC change in temperature). In this study, we set out to quantify the temperature dependence of essential parameters that define spatiotemporal behavior of cardiac...
As the thermoregulation centres are deep in the brain, the cerebral temperature is one of the most important markers of fever, circadian rhythms physical and mental activities. However due to a lack of accessibility, the brain temperature is not easily measured. The axillary, buccal, tympanic and rectal temperatures do not reflect exactly the cerebral temperature. Nevertheless the rectal temperature...
As the thermoregulation centres are deep in the brain, the cerebral temperature is one of the most important markers of fever, circadian rhythms physical and mental activities. However due to a lack of accessibility, the brain temperature is not easily measured. The axillary, buccal, tympanic and rectal temperatures do not reflect exactly the cerebral temperature. Nevertheless the rectal temperature...
Biomedical protocols based on thermal infrared images often require effective image registration. Algorithms specifically designed for registration of thermal images are hardly available and use of algorithms designed for other imaging techniques may result poorly reliable. In fact, registration algorithms developed for other biomedical images often require rigid-body assumption or limited range for...
Biomedical protocols based on thermal infrared images often require effective image registration. Algorithms specifically designed for registration of thermal images are hardly available and use of algorithms designed for other imaging techniques may result poorly reliable. In fact, registration algorithms developed for other biomedical images often require rigid-body assumption or limited range for...
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