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Alternative splicing of pre-mRNAs is a major mechanism of generating protein diversity in higher eukaryotes. It is well known that one of the major forms of alternative splicing is exon skipping, which alternatively skips specific exon during splicing. Previous research, by Miriami and his colleagues, was conducted by using a statistical method to identify two motifs both in upstream and downstream...
This paper discusses about several combinations of protein similarity measurement-methods, with respect to normalization, spatial partitions, geometrical properties, and distance metrics. We compare the effectiveness of possible combinations to each other. Our experiment shows that the feature based on fractional occupancy outperforms other methods. In addition, merging individual features might also...
The availability of a direct pathway from a primary sequence (denovo or DNA derived) to macromolecular structure to biological function using computer-based tools is the ultimate goal for a protein scientist. Today's state of the art protein resources and on-going research and experiments provide the raw data that can enable protein scientists to achieve at least some steps of this goal. Thus, protein...
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