The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
TNFalpha stimulates SPHK in the monocyte, which leads to the expression of adhesion molecules on the cell surface. The adhesion of leukocytes to the endothelium is one of the early stages of the onset of atherosclerosis. In this paper, we have delineated the TNFalpha-induced and SPHK-dependent signaling pathway. In addition, we have developed a biomathematical model to qualify the SPHK time-dependent...
We developed a reflectance continuous-wave near-infrared spectroscopy topography system with multi-source and multi-detector sensor head. A single wavelength (808 nm) laser diode is used as the original light source. With different-measurement approach, we can reconstruct images representing the variety of cerebral blood volume in clinical applications. Phantom experiments have been taken to verify...
A pocket blood sugar apparatus tested by enzyme electrode, which was designed using carbon and silver plasma as conducting materials. Both the work and reference electrodes are applied to the parts of enzyme electrode. The glucose oxidase is taken as the medium of blood sugar measuring. And the range of measuring glucose is about 50mg/dL - 500mgl/dL. It has better linear for the results and fit coefficient...
A novel disposable lactate biosensor was reported, which can measure the lactate in whole blood and other bio-fluids rapidly, accurately, expediently and directly. The biosensor was based on two kinds of electron mediator, the ferricyanide and the modified carbon nanotubes (CNT). Lactate oxidase (LOD) was coated on the electrodes. The sensor was fabricated by screen-printed techniques, the sample...
The carbon nanotube modified biosensors for respectively monitoring uric acid (UA) and total cholesterol in blood were studied. The transducers were based on two screen-printed carbon electrodes, a carbon working electrode and a reference electrode. For UA sensors, uricase was immobilized on the surface of electrodes together with potassium ferrocyanide as electron transfer mediator. For cholesterol...
In this paper, a simulation model of glucose-insulin metabolism for Type 1 diabetes patients is presented. The proposed system is based on the combination of compartmental models (CMs) and artificial neural networks (NNs). This model aims at the development of an accurate system, in order to assist Type 1 diabetes patients to handle their blood glucose profile and recognize dangerous metabolic states...
The study was to investigate thrombolysis in vivo with ultrasound, and to discuss effects of thrombolysis with ultrasound on the structure of erythrocyte and its safety threshold, under different ultrasound intensity and exposure time. The structure of erythrocyte in thrombus was evaluated under light microscope. The relationship between the structure of erythrocyte in thrombus and ultrasound intensity...
A droplet-based microfluidic system was developed for biochemical assays of triglycerides and methanol as potential applications in medical rapid diagnostics and food safety. We present a novel platform to manipulate biology reaction droplets with features of self-moving, self-mixing, and self-positioning toward the detection spot. The driving force comes from the gradient of surface tension force...
Barcode technology has been widely employed in medicine and healthcare industry. In this paper, it firstly introduces the application of barcode technology in information automation system oriented to blood banks and other transfusion facilities. In the following, the label paradigm of Codabar in Macao Blood Transfusion Center (CTS-Macau) is examined through the comparison with ISBT 128, an international...
As a patient and recipient of a blood transfusion, it is important for him or her to receive the safest blood possible. Information about the donated blood should be under the track to guarantee the quality of the blood source. In this paper, we present a RFID-based blood information management system that aims at ensuring the quality of the blood and increasing the efficiency of operation management...
The clinostat was originally used to find out why plant roots appear to grow predominantly toward the center of the Earth. Over the last 2-3 decades, slow- and fast-rotating 2D and 3D clinostats have been used to assess cellular adaptation to this environment. A cell culture is placed in a spin module of the clinostat platform and its rotation is set empirically (2-3 rpm). The machine is then allowed...
Cerebral oxygenation especially regional cerebral oxygen saturation (rSO2) needs to be monitored to avoid irreversible damages induced by hypoxia. Based on steady-state spatially resolved spectroscopy (SRS), rSO2 was obtained by the NIRS oximeter developed by our group. The oximeter was calibrated by blood gas analyzer using the liquid tissue model made up by our group. The results indicate that the...
We evaluated three non-invasive method, thermography, laser Doppler imaging and near infrared multi-spectral imaging to quantitatively assess parameters of vascularity in Kaposi's sarcoma. The KS lesion generally has increased temperature, blood velocity and blood deoxy-hemoglobin. There is a strong correlation between temperature and blood velocity (R= 81, p<0.001). After treatment with experimental...
Blood oxygenation level dependent (BOLD) functional MRI and near infrared optical tomography have been widely used to investigate hemodynamic responses to functional stimulation in the human brain. In this paper, we present a complete methodology for integrating the two imaging modalities to study the underlying physiological mechanism of the hemodynamic response in primary visual cortex. Using a...
GLUCOSIM is an educational software package that simulates blood glucose and insulin dynamics in healthy individuals and patients with type 1 diabetes. It is being used to assist biomedical and chemical engineering students in visualizing the dynamic variations in blood glucose concentration in response to external variations such as food consumption and insulin administration. A nutritional database...
For better understanding of genetic mechanisms underlying clinical observations, we often want to determine which genes and clinical traits are interrelated. We introduce a computational method that can find co-clusters or groups of genes and clinical parameters that are believed to be closely related to each other based upon given empirical information. The proposed method was tested with data from...
The response of the metabolic network of human red blood cell is investigated using the E-Cell simulation system when pyruvate kinase (PK) is deficient. The results that several downstream metabolites of the glycolysis pathway accumulate are in a good agreement with experimental data reported in literatures. This accumulation results in the reaction that phosphoglycerate kinase (PGK) catalyzes reversing...
Although plasma catecholamines such as norepinephrine (NE) and epinephrine (Epi) increase during severe exercise, the effects of high levels of plasma catecholamines on dynamic heart rate (HR) regulation by the cardiac sympathetic nerve remains unknown. The aim of the present study was to examine the effects of plasma catecholamines on the transfer function from sympathetic nerve stimulation to HR...
We report a MEMS device for continuous and binary separation of leukocytes (white blood cells, WBCs) and erythrocytes (red blood cells, RBCs) by their sizes. The system consists of PDMS cylindrical pillars inside fluidic chamber on glass slides. A 420 mum lateral separation was achieved for 5 mum and 10 mum beads. The critical particle size for separation was successful predicted by simulation and...
Independent component analysis (ICA) is widely used for signal separation in various fields. However, low signal to noise ratio (SNR) of data sometimes causes failures in component estimation. We have proposed a spatial ICA-based method for extracting a blood-related component from medical images measured with positron emission tomography (PET) to omit arterial blood sampling, in which a cost function...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.