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Nanometer-sized particles have novel optical, electronic, and structural properties that are not available from either individual molecules or bulk solids. When linked with tumor targeting ligands such as monoclonal antibodies, these nanoparticles can be used to target tumor antigens (biomarkers) as well as tumor vasculatures with high affinity and specificity. In the "mesoscopic" size range...
Renal tumors are classified into histopathologic subtypes based on light microscopy. Classification is important because subtypes have distinct genetic abnormalities and clinical behavior, yet is difficult because many cases have heterogeneous morphology. Thus, several molecular assays have been developed for tumor classification. Immunohistochemistry (IHC) permits correlation of molecular data with...
Cryosurgery is a minimally invasive surgical technique that employs the destructive effect of freezing to eradicate benign or malignant tumors which are difficult or even impossible to be extirpated by conventional surgery. Recently, we proposed a method for flexibly controlling the freezing scale during cryosurgery by percutaneously injecting thermally important functional solutions into the target...
Vascular injury is an important damage mechanism of cancer treatment modalities such as cryotherapy and hyperthermia. In this study, tumor microvasculature response to locally alternated cold and heat treatment has been studied via microscope observation and histopathological analysis. The tumor vascular permeability to Rhodamine labeled 100 nm liposomes at different temperatures was quantitatively...
Realgar, one of mineral drugs in Chinese traditional medicines has attracted an increasing attention because of its prominent anti-tumor effect. However, new challenges for improving its bioavailability has to be faced. Our previous studies have demonstrated that realgar nanoparticles may provide a less toxic agent for anti-neoplasia by suppressing angiogenesis. In the present study, we improved milling...
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