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TNFalpha stimulates SPHK in the monocyte, which leads to the expression of adhesion molecules on the cell surface. The adhesion of leukocytes to the endothelium is one of the early stages of the onset of atherosclerosis. In this paper, we have delineated the TNFalpha-induced and SPHK-dependent signaling pathway. In addition, we have developed a biomathematical model to qualify the SPHK time-dependent...
We evaluated three non-invasive method, thermography, laser Doppler imaging and near infrared multi-spectral imaging to quantitatively assess parameters of vascularity in Kaposi's sarcoma. The KS lesion generally has increased temperature, blood velocity and blood deoxy-hemoglobin. There is a strong correlation between temperature and blood velocity (R= 81, p<0.001). After treatment with experimental...
A novel imaging scheme integrating a continuous wave (CW) hand held near infrared tissue imager and a portable ultrasound probe was proposed for evaluation of suspicious breast lesions. A new methodology was developed to reconstruct functional properties of the lesion and the surrounding tissue based on the optical measurement of the diffusive light and the ultrasound measurement of the tumor morphology...
Ultrasound induced blood stasis has been observed for a long time, but to date most experimental observations have been in vitro. In this paper we discuss a possible diagnostic use for this previously undesirable effect of ultrasound - tumor detection in vivo. We demonstrate that, using optical spectroscopy, effects of ultrasound can be used to differentiate tumor from non-tumor in murine tissue....
The study was designed to observe the effects of 50 Hz homogeneous ferromagnetic field (0.097 T) exposure on change of intracellular calcium-ion concentration of human low differentiation gastric adenocarcinoma cell line SNU and lymphocytes in vitro. SNU cells and human peripheral blood lymphocytes in vitro were exposed to 50 Hz homogeneous ferromagnetic field at different time periods. Cells were...
Chemohyperthermic tumor treatment has developed quite rapidly over the past 20 years, and its therapeutic effect is widely known from clinical practice. More recently it has been realized that whole-body chemohyperthermic tumor treatment by extracorporeal circulation is quite a unique approach with which the patient's blood is withdrawn from femoral artery through a peristaltic pump to a heat-exchanger...
Perfusion normally refers to the delivery of blood at the level of capillaries. Hemodynamic perfusion magnetic resonance (MR) imaging has been used in clinics for a series of applications including tumor characterization (histological type diagnosis and grading), diagnosis and the follow up of stroke, and several other disorders. For this study a platform to investigate the theoretical basis of perfusion...
This paper introduces the new qualitative and quantitative methods, which can diagnose breast tumors. Qualitative methods include blood vessel display inside and outside of pathological changes part of breast, display of equivalent pixel curves at the part of pathological changes and display of breast tumor image edge. Accordingly, three feature extraction operators are proposed, i.e. the combination...
Here, a filter with series of pools and dams structures was designed and fabricated, utilizing size difference between tumor and blood cells. The cell mixtures were successfully filtrated out by the filter, and separation efficiency was up to 99.9%. To evaluate the filter, physical models were made to describe the behaviors of different cells in microfluidic systems. As the ability of cell deformation...
Realgar, one of mineral drugs in Chinese traditional medicines has attracted an increasing attention because of its prominent anti-tumor effect. However, new challenges for improving its bioavailability has to be faced. Our previous studies have demonstrated that realgar nanoparticles may provide a less toxic agent for anti-neoplasia by suppressing angiogenesis. In the present study, we improved milling...
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