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For the gentle and non-destructive characterisation of small tissue samples, non-invasive methods are required for biotechnological applications and medical diagnostics. One approach is the characterisation of small tissue samples by impedance spectroscopy using a measuring capillary. In this paper, the applicability of a capillary measuring system to record the impedance of a biological sample over...
Nanosecond, megavolt-per-meter pulsed electric fields scramble the asymmetric arrangement of phospholipids in the plasma membrane, release intracellular calcium, trigger cardiomyocyte activity, and induce apoptosis in mammalian cancer cells, without the permeabilizing effects associated with longer, lower-field pulses. Dose dependencies with respect to pulse width, amplitude, and repetition rate,...
Here, a filter with series of pools and dams structures was designed and fabricated, utilizing size difference between tumor and blood cells. The cell mixtures were successfully filtrated out by the filter, and separation efficiency was up to 99.9%. To evaluate the filter, physical models were made to describe the behaviors of different cells in microfluidic systems. As the ability of cell deformation...
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