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The accurate estimation of cerebral metabolic rate of O2 (CMRO2) is still an unavailable but highly desired clinical tool. The addition of a further experimental variable to near infra-red spectroscopy (NIRS) allows more information to be gained than has previously been possible. A physiological model is presented here that can be used to estimate CMRO2 from measurements of oxy- and deoxy- haemoglobin...
To meet needs in cell and tissue engineering bioreactors are evolving to allow cells and tissues to be cultured under precisely defined physical and chemical conditions. Many cell-tissue types are now being cultured, and considered in this work are chondrocytes, vascular endothelial cells, and smooth muscle cells. The culture processes are dynamic and optimisation requires monitoring of key process...
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