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The finite difference time domain (FDTD) analysis based on nonuniform grids for solving the diffusion equations in biological tissue has been proposed. It has been confirmed that the analysis greatly reduce the time for calculating time-resolved reflectance in three-dimensional scattering medium preserving the numerical accuracies. Based on the analysis, noninvasive optical parameters determination...
A novel algorithm has been developed for near infrared (NIR) imaging of tissue optical properties with embedded heterogeneity. The algorithm was based on the optical measurements of the absorption perturbation by a matrix of multiple source detector pairs. Direct superimposition algorithm was used to calculate the two dimensional projected image of the tissue absorption. This absorption map is then...
Chronic wounds represent one of the most serious complications of diabetes. Lack of quantitative assessment of healing progress makes diabetic wound management a clinical challenge. We constructed an optical device based on near infrared diffuse optical spectroscopy and monitored the change in wound optical properties during healing. A single source, four detector frequency domain instrument with...
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