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Voltage gated ion channels activate in response to step changes in voltage but slowly inactivate even though the voltage is maintained. It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the channel. The authors derived the statistical properties of this model so that it can be quantitatively tested...
Stretch-activated ion channels (SACs) in myocytes isolated from neonatal rats were studied in cell-attached patches. Stretch was applied to cell-attached patches by suction (5-20 mm Hg) in the recording pipet. Stretch caused the triggering of action potentials that were recorded in cell-attached patches as biphasic action currents (ACs). The significance of a temporal correlation between SAC open...
The present study was designed to evaluate the effect of weak, environmental range, AC and DC magnetic fields on myosin light chain phosphorylation in a cell-free system. The exposure system applied AC (16 Hz, 20.9 mu T) and DC (0-200 mu T, vertically and/or horizontally) magnetic fields. The results suggest that all of the AC, DC, and combination AC/DC magnetic fields significantly (30-100%, p<...
A review of the empirical observations of ELF electric field effects on living tissue has led the authors to propose that effects occur through the action of the electric polarization forces which develop at the cell surface. Such an interaction mechanism predicts that the field effects should be associated with a time-development response as well as an actual deformation of the exposed cell. These...
The authors derive a compartmental model for oxygen transport in vascular blood which is suitable for both steady and time-varying analysis, and which can be used with any kind of oxygen dissociation function. The derivation focuses on the establishment of expressions for the lumped convective term and the lumped oxygen dissociation function. Results of the simulation show that the value of the lumped...
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