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A circuit was developed to serve as an interface from an intact biological neuron to an electromechanical device. The circuit is a custom VLSI IC that contains a highly sensitive buffer, a neuron-like threshold discriminator, and a dedicated four-phase output driver. Nerve-like in behavior, the circuit detects action potentials from living nerve tissue, and if the activity exceeds a given threshold,...
Receptor function is being investigated by incorporating naturally occurring membrane-based biological recognition elements into surface structures interfaced with microelectronic substrates. Alkylsilane molecules, formulating one half of a bilayer membrane mimetic structure, were covalently bound to the surface of Si/SiO/sub 2/ electrodes and interdigitated microsensor electrode devices. In addition...
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