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There are established macroscale fabrication methods to create parts of virtually any shape or size; but for components in the microscale range (thousands to tens of microns) there is a dearth of options for making 3D parts at high enough throughput to make them practical. This paper demonstrated a novel method to create novel micromolding processes that are capable of creating defect-free microscale...
DNA-assisted assembly has been demonstrated as a powerful method for synthesizing plasmonic nanostructures possessing electromagnetic hot spots for surface-enhanced Raman spectroscopy (SERS). In this work, we use DNA molecules as linkers to synthesize core-satellite nanostructures for SERS molecular detection. The interparticle distance, which is critical to Raman enhancement, is fine-tuned by growing...
Organ-on-chip systems harness microscale tissue fabrication techniques to reproduce models of human tissue. These models rely on the development of synthetic and biological scaffolds to support 3D cell culture. Herein, we present a microfluidic platform that uses laminar flow generated in a Y-channel to fabricate a gelatin methacrylamide (GELMA) scaffold. As a pilot study, we characterize the effect...
Self-constructing materials, which can spontaneously change their shapes from ordinary two-dimensional (2D) planes into complex three-dimensional (3D) structures, are always an attractive subject of intelligent materials. Herein, we report a simple yet effective strategy for the fabrication of programmable, thermally responsive and self-constructing hydrogels which can undergo various types of transformation...
This paper presents the fabrication, characterization and application of PEDOT-ionic liquid composite films modified Au microelectrodes. Here only one-step electropolymerization was required for the preparation of PEDOT-BMIMBF4 and PEDOT-BMIMPF6 composite films, which were investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscope (SEM), and...
A droplet-born air-blowing method is an advanced method of the drawing lithography enables simple and fast fabrication, which does not require UV irradiation or moulding process. However, it has disadvantages such as low throughput in the formation of droplet array as it uses the dispenser to make droplets one by one. To increase the throughput while also simplifying the fabrication method, we suggest...
Drug delivery system (DDS) is the process of administering a drug-loaded composite to achieve a therapeutic effect in vitro or in vivo. In this paper, we present the fabrication of imiquimod-poly(ε-caprolactone) (PCL) fibre meshes for the melanoma therapy application. The fabrication was based on the electrospinning technique and NIH-3T3 fibroblast cells were cultured on electrospun fibre meshes to...
The importance of generating a microvessel network in vitro lies in the ability to engineer vital tissue of considerable size or working as a platform for biomedical or cardiovascular studies. However, most of the current methods for generating microvessel networks in vitro based on encapsulating the channel structure inside an extracellular matrix like gel, which requires a circulation pumps at the...
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