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Monotonic scaling-down of CMOS integrated circuit (IC) technologies is rapidly approaching to its physical end, yet advances in ICs will continue. Instead of one-dimensional (1D) scaling dawn, one apparent solution is lateral integration of heterogeneous devices in 3-dimensional (3D) fashion, which opens great opportunities to make more complex Si-based microsystems for unlimited applications well...
Currently, sorafenib is the only systemic therapy capable to increase the overall survival of the patient affected by advanced hepatocellular carcinoma. Unfortunately, its side effects limit the therapeutic response. Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery as they can be targeted to specific sites in the body through the application of a magnetic field,...
This study reports a magnetic-bead based microfluidic system to capture cholangiocarcinoma cells by using structurally well-defined heparan sulfate (HS) octasaccharides. Ten synthetic HS octasaccharides (from SCH-43 to SCH-52) were coated on magnetic beads for this study, respectively. An integrated microfluidic system equipped with micromixers, normally-closed valves, and microchambers was developed...
In this report, we present an atomic force microscopy cantilever with µm-sized magnetoresistive sensors integrated at its tip for scanning magnetoresistance applications. Simultaneous topographic and magnetic maps are generated with a spatial resolution better than 1 µm by means of a two-dimensional scan over an area of 100×100 µm2. Experimental results validate that our scanning technique is capable...
A simple, highly sensitive magnetic immunoassay three dimensional optics biosensor based on total internal reflection magnetic imaging (TIRMI) was fabricated for the point-of care testing (POCT) of C-reaction protein (CRP). The chip substrate is formed by the combination of a 3D glass substrate and a plate polymethyl methacrylate (PMMA) substrate by close bonding of glass optical glue. The micro channel...
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