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A rapidly prototyped microfluidic device made of glass microscope slides and polydimethylsiloxane (PDMS) was developed to characterize impedance changes during the developmental stages of Artemia cysts. The device was designed to measure the impedance of a single cyst. The device performance was tested by measuring the impedance of Artemia cysts until they hatched. The measured impedance corresponded...
The purpose of this study was to develop a microelectromechanical systems compatible process (e.g., etching, lithography, sputtering) for a polyimide (PI) substrate. A thin-film transistor (TFT) array on the flexible substrate was demonstrated by fully etching aluminum (Al), indium gallium zinc oxide (IGZO), and aluminum oxide (Al2O3). Moreover, during the sputtering process, the surface roughnesses...
For the first time, this paper investigates anodic bonding using the latest chemically-strengthened glass called Gorilla Glass (from Corning). Gorilla Glass has many excellent properties for MEMS/NEMS applications, including hardness (resistance to scratching), flexibility, high fracture toughness and antibacterial resistance. However, the high thermal expansion coefficient of Gorilla Glass (7.58ppm/°C)...
Currently, sorafenib is the only systemic therapy capable to increase the overall survival of the patient affected by advanced hepatocellular carcinoma. Unfortunately, its side effects limit the therapeutic response. Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery as they can be targeted to specific sites in the body through the application of a magnetic field,...
This study reports a magnetic-bead based microfluidic system to capture cholangiocarcinoma cells by using structurally well-defined heparan sulfate (HS) octasaccharides. Ten synthetic HS octasaccharides (from SCH-43 to SCH-52) were coated on magnetic beads for this study, respectively. An integrated microfluidic system equipped with micromixers, normally-closed valves, and microchambers was developed...
In this work, we present a new microfluidic particle-analyzing device with a spatially coplanar-electrode design. To achieve effective particle analysis, 4 coplanar electrodes were designed and fabricated on glass substrates. Different from traditional cross-channel electrodes in impedance sensing, the coplanar design can be achieved without precise alignment issue, which is the major obstacle of...
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