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Epidural spinal cord stimulation (SCS) is a promising therapy for spinal cord injury (SCI). This paper combines experimental data from epidurally-stimulated human paraplegic patients with computational models of SCS to identify the electric field features correlated with the patients' ability to stand. We locate the spinal cord regions most critical to stimulated standing and find that the most informative...
Deep brain stimulation (DBS) is an established therapy for a variety of neurological disorders, including Parkinson's disease, essential tremor, and dystonia. Recent DBS research has pursued methods for closed-loop control to provide more effective management of symptoms, side effects, and device power consumption. Most closed-loop DBS (CLDBS) studies to date use simple threshold-based controllers...
Generalized linear models (GLMs) are useful tools to capture the characteristic features of spiking neurons; however, the long-term prediction of an autoregressive GLM inferred through maximum likelihood (ML) can be subject to runway self-excitation. We explain here that this runaway excitation is a consequence of the one-step-ahead ML inference used in estimating the parameters of the GLM. Alternatively,...
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