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This paper presents an original framework based on deep learning and preference learning to retrieve and characterize biomedical images for assisting physicians in diagnosing complex diseases with potentially only small differences between them. In particular, we use deep learning to extract the high-level and compact features for biomedical images. In contrast to the traditional biomedical algorithms...
Mitigating pathological synchrony of neurons in basal ganglia networks was considered as one of the potential mechanisms of deep brain stimulation (DBS) in treating Parkinson's disease. Motivated by reducing the energy of external stimuli, optimal control strategies are presented to regulate DBS waveform so as to mitigate synchronous oscillations of neural networks with fewer energy expenditure. In...
The fundamental role of the cerebellum in motor learning explains the deficits of cerebellar patients in adaptation to a changing environment. For example, lesions to the cerebellar cortex compromise performance during tasks like reaching a target under a force field perturbation. However, the exact relationship between neural damages and misbehaviors still needs to be clarified. To this aim, it could...
Deep brain stimulation (DBS) is an established therapy for a variety of neurological disorders, including Parkinson's disease, essential tremor, and dystonia. Recent DBS research has pursued methods for closed-loop control to provide more effective management of symptoms, side effects, and device power consumption. Most closed-loop DBS (CLDBS) studies to date use simple threshold-based controllers...
Transcutaneous Electrical Nerve Stimulation (TENS) attracts extensive attention in neuromodulation due to its minimal invasiveness. Conventional TENS uses non-invasive surface planar electrodes attached to the skin for delivering the stimulation current to modulate neural circuitries. Previous studies have shown that using these surface planar electrodes in TENS therapy may cause stimulation-induced...
The ability to detect noxious stimuli and evoke a defensive response is made possible by specialized peripheral sensory neurons called nociceptors that respond to stimuli such as extreme temperature, pressure and injury. A number of experimental studies have been done on nociceptors at various range of temperatures in order to understand the underlying biophysical mechanisms. Simple models for describing...
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