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Simultaneous PET/MRI shows great promise for improved detection and diagnosis of disease. Commercially available whole body combined PET/MRI systems are currently prohibitively expensive, limiting access to the technology. MRI-compatible PET inserts present a lower-cost alternative, adding PET capabilities to existing MRI installations. A brain sized radio-frequency (RF)-penetrable PET insert has...
Image-domain dual-energy CT (DECT) is practical and critical for medical diagnosis and treatment evaluation. The bottleneck of DECT imaging is the significantly magnified noise after a direct inversion decomposition. A good balance is not readily achievable between noise suppression and spatial resolution maintenance. Noise suppression is conventionally included in DECT decomposition implicitly or...
THE spatial bias and covariance characteristics of reconstructed PET data are important as routine assessments of image quality in PET scanners [4], [5]. Our previous empirical analysis of uniform Phantom data across the 43 sites in ACRIN [2] shows that both spatial bias and covariance can be decomposed as a product of a trans-axial radial function and axial function [1]. On the basis of this decomposition,...
BREAST cancer is the most common cancer in women [1]. High-resolution, breast-dedicated PET can provide complementary information to guide cancer management, alongside traditional imaging modalities such as mammography, MRI, and ultrasound [2]. A dual-panel PET camera dedicated to breast imaging (Fig. 1) is being constructed and tested in our lab, with high sensitivity, 1mm3 spatial resolution, and...
PET scanners are designed to function over a wide dynamic range of imaging conditions. Clinical constraints, such as injected activity and imaging time, often limit the realization of optimal system capability. The ‘working range’ of image quality for a given imaging situation is dictated by a trade-off of signal to noise. By adjusting scan time and reconstruction parameters, an acceptable trade-off...
Scanners with different performance characteristics and reconstruction protocols can produce images that show large variations in uptake in small lesions. There have been a number of studies aimed at reducing this variability for clinical trials using phantom data to optimize the acquisition and/or reconstruction protocols. The underlying assumption is that the protocols that harmonize the phantom...
We are developing brain SPECT system with excellent spatial resolution less than 5 mm like PET system. In this study we developed a full-digital gamma camera with position-sensitive photomultiplier tube (PMT) to achieve high spatial resolution and constructed SPECT system using it. In addition, we evaluated the performance of the developed gamma camera and SPECT system.
PET lesion detectability performance characterization with clinically relevant background conditions is difficult to perform with existing phantoms and inserts. The backgrounds of conventional phantoms are often uniform water regions with lesions represented as tillable chambers with casings that create a region of zero activity surrounding the high-activity feature. 3D-printing has enabled the creation...
Digital breast tomosynthesis (DBT) is most commonly used in three-dimensional (3D) mammography because it provides a 3D view, so suspected tumors and massed in the breast can be detected with a higher degree of accuracy. Conventional DBT reconstruction methods are based on the filtered-backprojection (FBP) with an additional deblurring filter. However, this approach usually requires dense projection...
Using a medium and large sized anthropomorphic cardiac-torso phantoms we studied the effects of TOF and PSF to evaluate Rb-82 cardiac imaging of large patients. The reconstructed images were analyzed for recovery coefficient and RMS deviations on the polar plot data. Modelling PSF resulted in higher recovery coefficients while the reconstructions with TOF yielded reduced RMS deviations compared to...
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