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We propose an on-chip integrated differential optical silicon nitride microring biosensing platform which uses a dual laminar flow scheme. This platform reduces the fabrication complexity involved in the fabrication of the reference resonator.
We report on a record 2% extracted optical-to-terahertz conversion efficiency in the mm-wavelength range through optical rectification in cryogenically-cooled lithium niobate by exploiting spatial and temporal shaping of the optical pump beam.
X-ray FEL facilities place challenging demands on the stability and configuration of ultrafast optical lasers for user experiments; future facilities will push the frontiers for high peak and average power ultrafast lasers.
We demonstrate a field-portable optofluidic plasmonic sensing device, weighing 40 g and 7.5 cm in height, which merges plasmonic microarrays with dual-wavelength lensfree on-chip imaging for real-time monitoring of protein binding kinetics.
We present a new approach to realize liquid-core optical waveguides via selective wetting on lithographically patterned oleophobic and oleophilic patches for sensing and adaptable optics applications.
We report on the initial results of the first automated classifier to distinguish basal cell carcinomas and healthy skin using polarization sensitive optical coherence tomography (PS-OCT) with a sensitivity and specificity of 84.2% and 85.8%.
Mid-infrared VECSEL tunable over 50 cm−1 is employed to measure trace gas concentrations of acetone in human breath. A detection limit of 25 ppb is demonstrated without any sample preparation.
Although the genomes of many animals, from worms to humans, have been sequenced, much of the detailed molecular understanding of the biology of these genes and their proteins is unknown. One of the major problems is that we cannot currently see what a protein does, where it is, and how it moves. Thus, most functional conclusions about a protein are necessarily indirect. The visualization of the structure...
High resolution, full-field tomograms are acquired in four exposures of a CCD camera using a swept laser. The imaged depth is selected by modulating the swept laser output power enabling volumetric imaging with no moving parts.
A more than two-octave mid-infrared supercontinuum with an average output power of 15.6 mW covering 1.7–7.5 μm (1,333–5,900 cm−1) is generated in a low-loss As38Se62 suspended core fiber with core diameter of 4.5 μm.
We have developed an all-optical approach to measure material mechanical properties using Brillouin light scattering. Brillouin imaging uses the elastic modulus as contrast mechanism. We demonstrate its application in vivo for tissue and cellular biomechanics.
We have developed a label-free microcavity biosensing platform that is capable of monitoring single DNA molecules and their interaction kinetics, hence achieving an unprecedented sensitivity in the optical domain.
Dielectric laser acceleration of electrons is the optical counterpart of phase-synchronous RF-acceleration of electrons in classical accelerators, demonstrated by us and at Stanford/SLAC recently. We discuss concept, experiments and detail highlights of this high-gradient scheme.
We demonstrate a new method for pump-probe spectroscopy by applying arbitrary detuning asynchronous optical sampling (AD-ASOPS) to two independent amplified laser systems. The resulting time dynamics ranges from 400 fs up to 1 ms.
A quantitative polarization sensitive optical coherence tomography (PS-OCT), so called Jones matrix (JM-) OCT is presented. This system measures the Jones matrix tomography of biological and medical samples. Jones matrix based signal processing and numerical estimator algorithm are then applied to obtain truly quantitative value of tissue birefringence. The clinical utility of JM-OCT is examined by...
Label-free nonlinear optical molecular imaging methods could enable the rapid, reliable, and non-invasive assessment of living tissue-engineered constructs, potentially addressing a critical regulatory requirement in tissue engineering and regenerative medicine.
We have presented linear-in-wavenumber swept laser and all-optical 40MHz swept-source as the optical source, and compressed sensing and time serial optical computing to process the massive imaging data for real time 3D optical coherence tomography imaging.
We review results of 10 joint research projects on ultrashort pulse technology. Topics include novel laser sources, reliable components and specialized applications from eye surgery to processing of semiconductors, carbon fiber reinforced plastics and metals.
A three-stage optical parametric amplifier is built to produce 1 kHz, 31 fs, ∼200 μJ signal pulses with tunable wavelengths. Red-activatable channelrhodopsin in fruit fly is optimally two-photon excited to copulation behavior at 1250 nm.
Interferometric imaging offers many advantages for biomedical applications such as optical sectioning/depth resolution. Inclusion of molecular contrast information improves utility but requires additional efforts to either isolate spectroscopic information or detect contrast agents.
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