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The next generation sequencing technology has enabled the understanding of the whole genome of an organism at a greater coverage and reduced cost. In this study, we provide a systems biology approach to understand the functional relevance of the single nucleotide variants identified by the whole genome sequencing studies. This approach also includes a methodology for the identification of conserved...
Continued advances in next generation short-read sequencing technologies are increasing throughput and read lengths, while driving down the error rates, for example within 1% for Illumina HiSeq reads. Moreover, the errors are not uniformly distributed in all reads, and a large percentage of reads are indeed error-free. Ability to predict such perfect reads can have significant impact on run-time complexity...
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