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Indirect ImmunoFluorescence (IIF) is currently the recommended method for the detection of antinuclear autoantibodies(ANA). It is an effective technique to reveal the presence of auto immune diseases; however, it is a subjective method and hence dependent on the experience and expertise of the physician. Moreover, inter-observer variability limits the reproducibility of IIF reading. To this end, we...
Automation of HEp-2 cell pattern classification would drastically improve the accuracy and throughput of diagnostic services for many auto-immune diseases, but it has proven difficult to reach a sufficient level of precision. Correct diagnosis relies on a subtle assessment of texture type in microscopic images of indirect immunofluorescence (IIF), which so far has eluded reliable replication through...
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