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Large-scale biophysically detailed computer models of the heart provide a useful tool to understand dynamics of cardiac excitation and mechanisms underlying lethal cardiac arrhythmias. However, high demanding of intensive high performance computing environments limits the practical application of such models. This paper presents a novel use of a desktop personal computer and the CUDA parallel computing...
The study of cardiac arrhythmias is a major focus of computational biology, and undertaking biophysically detailed simulations is computationally demanding. An efficient coupled electromechanical solver to model cardiac tissue has been developed. This provides features to model fibre direction, and utilises computationally efficient techniques to reduce the simulation times. In this paper the break...
We study a model of the atrioventricular node function during atrial fibrillation (AF), for which the model parameters can be estimated from the ECG. The proposed model is defined by parameters which characterize the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two atrioventricular nodal pathways, the refractory periods of these pathways, and the prolongation...
The heart consists of myocytes, vasculature cells and connective tissue cells. In this study, two ventricular electromechanical models were coupled with the fibroblast model. At the cellular level, Niederer-Smith (NS) model of rat ventricular myocyte and ten Tusscher model of human ventricular myocyte and the passive fibroblast model are combined with Rice model of contraction and cooperativity mechanisms...
Electrocardiographic wave forms during the QRS interval reflect the activation sequence of the heart. This can be demonstrated in ECGSIM, an interactive software package aimed to support ECG education and research. When using this package, the timing of activation may be changed interactively, either locally or globally. The resulting QRS changes are displayed instantaneously. We describe a new feature...
Computer models are frequently used for scientific research. Since scientific models are usually targeted at a specific application, using them in an educational setting is not straightforward. At Maastricht University, the CircAdapt model of heart and circulation has been developed as a scientific research tool. The model describes hemodynamic interaction between the left and right ventricle as well...
We study, if mechanisms for the generation of fibrillation patterns observed recently in studies of the FitzHugh-Nagumo (FHN) model can be seen also in the model of Bueno-Orovio, Cherry and Fenton (BOCF), that has been adapted specifically to the atrial electrophysiology. The mechanisms are associated with the interference of two spatially separated pacemakers that are connected by a small bridge...
The existing works of electrocardiogram (ECG) simulation generally use a static or so called ”one-way” electromechanical coupled heart model. However, electrical and mechanical activities of the heart are inter-dependent, and realistic ECG simulation can only be achieved when such coupled relationship is considered. In this paper, we propose an electromechanical coupled heart model that includes both...
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