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Entropy, as a measure of randomness in time-varying signals, is widely used in areas such as thermodynamics, statistical mechanics and information theory. This paper investigates the use of two commonly employed entropy measures, namely Wavelet Entropy and Approximate Entropy, as a predictor of tremor reappearance in Essential Tremor patients; the predictor input is a raw surface-electromyographic...
Although deep brain stimulation (DBS) therapy has been achieved, fine tuning on the operational parameters and the equipment are needed in order to make the stimulation treatment more applicable. Thus, the purpose of this study is to design and produce a deep brain stimulation device for DBS experiments for small animals (e.g. rats). Physical size, durability, cost of device and convenience of operation...
DEEP brain stimulation implants have improved life quality for more than 70,000 patients world-wide with diseases like Parkinson's, essential tremor, or obsessive-compulsive disorder where pharmaceutical therapies alone could not offer sufficient relief. Still, optimization and monitoring relies heavily on regular clinical visits, putting a burden on patient's comfort and clinicians. Permanent monitoring...
Deep brain stimulation (DBS) within the basal ganglia complex is an effective neurosurgical approach for treating symptoms of Parkinson's disease (PD), Essential Tremor, Dystonia, Depression, Obssessive Compulsive Disorder, and Tourette's Syndrome, among others. Elucidating DBS mechanism has become a critical clinical and research goal in stereotactic and functional neurosurgery and in neural engineering...
High frequency deep brain stimulation (DBS) of certain basal ganglia nuclei (e.g. subthalamic nucleus, STN) has emerged as a powerful neuromodulatory approach in the treatment of late stage Parkinson's disease patients. However, the underlying mechanisms of action are not fully understood. We have therefore established an implantable DBS device for small laboratory animals (e.g. rats) that allows...
In the context of drug resistant partial epilepsy, intra-cerebral electrical stimulation (Deep Brain Stimulation) constitutes one of the means of investigation to locate epileptic volume. This exogenous source can then activate the underlying epileptic networks and generate an electrophysiological reaction. The purpose of this work is to estimate and eliminate the overlapping electrical stimulation...
Closed-loop deep brain stimulation (DBS) systems offer promise in relieving the clinical burden of stimulus parameter selection and improving treatment outcomes. In such a system, a feedback signal is used to adjust automatically stimulation parameters and optimize the efficacy of stimulation. We explored the feasibility of recording electrically evoked compound action potentials (ECAPs) during DBS...
Treating epilepsy with deep brain stimulation (DBS) is attracting more and more attention these years, especially the close loop method that gives stimuli when needed so that the implanted device will work longer. People have tried to detect seizure with electrocorticogram (ECoG), but the extra implants put more risks to it. We plan to detect seizure with local field potential (LFP) that recorded...
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