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Burkholderia cepacia complex bacteria are opportunistic pathogens, causing severe lung infections in cystic fibrosis patients. Many clinical isolates produce the exopolysaccharide cepacian, believed to be an infection persistence determinant. Little is known about cepacian biosynthesis regulation, but our studies showed the importance of post-translational mechanisms mediated by tyrosine phosphorylation,...
Laser Doppler flowmetry (LDF) is a technique for real-time assessment of microcirculation blood flow. LDF can be used for non-invasive perfusion monitoring (for example skin perfusion monitoring), or for invasive microcirculation evaluations (for example perfusion brain evaluations). Using a multi-wavelength laser Doppler flowmeter prototype with different spaced detection fibers, we propose to add...
The social and economic impact of cardiovascular diseases and the importance of efficient early diagnostic tools are self-evident. This project finds its motivation in the foreseeable impact that an accurate, non-invasive and easy-to-use instrument for hemodynamic condition assessment could introduce on the diagnosis and follow-up of these diseases. It aims at developing and testing of a microcontroller...
Over the last years, great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. This hemodynamic parameter, generally associated to age and blood pressure increase, can be assessed by the measurement of pulse wave velocity (PWV). Currently available devices that measure PWV are expensive and need to be operated by skilled medical staff, reducing...
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