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This work focuses on an infant deafness detector unit, using the concept of microphone array. This instrument is based on the principle of evoked acoustic emissions (OAEs). The key feature of the microphone array is its ability to increase signal-to-noise ratio (SNR) and reproducibility of the OAE responses. These further significantly contribute to improve the sensitivity and specificity of the overall...
As the number of seniors with chronic disease increases, the need of home healthcare settop-box is increased to manage their chronic disease in their home environment. Using the home healthcare settop-box, the patients can regularly check their health data, and finally, it can lead the decrease of medical expenses. For the home healthcare settop-box, the most important factor is the standard compatibility,...
Lab-on-a-chip systems are increasingly applied in cell-based assays for toxicology and drug testing. In this paper, an on-chip integrated lensless microscopy module using a direct projection method for optical monitoring of the shadow images of adherent growing mammalian cells is presented. The biological cells are conserved and interfaced by a microfabricated cavity chip with a 1 μm thick silicon...
The objectives of this paper are to present a guideline-based decision support system (GBDSS) design for supporting patient telehealth management of chronic disease and to test its performance in correctly making referral recommendations using routinely recorded measurement data from home telehealth recordings. The GBDSS has been developed to manage lung disease patients in a home telehealth environment...
Model and simulation of biological systems help to better understand these systems. In ICUs patients often reach a complex situation where supportive maneuvers require special expertise. Among them, mechanical ventilation in patients suffering from acuter respiratory distress syndrome (ARDS) is specially challenging. This work presents a model which can be simulated and use to help in training of...
Human activity can be measured with actimetry sensors used by the subjects in several locations such as the wrists or legs. Actigraphy data is used in different contexts such as sports training or tele-medicine monitoring. In the diagnosis of sleep disorders, the actimetry sensor, which is basically a 3D axis accelerometer, is used by the patient in the non dominant wrist typically during an entire...
This paper presents our experience with developing a portable wireless medical sensor device. We use National Instruments (NI) devices and LabView for measurements studying fatigue of patients suffering multiple sclerosis (MS). Fatigue is a very frequent symptom perceived by MS patients, but the disease mechanism is poorly understood. Many efforts have been made to increase the understanding of this...
It is widely accepted and can be easily verified that any specific voxel in a class of brain single photon emission computed tomography (SPECT) volumes is of a univariate normal distribution. In this research, we conjecture that all the voxels in a class of SPECT volumes are also approximately of a multivariate normal (MVN) distribution from which in terms of the Bayes errors of statistics, an optimal...
A process for fabricating hafnium oxide (HfO) films to minimize ionic penetration was developed and tested. A 333Å HfO film was successfully deposited by thermal evaporation. The film was characterized through capacitance versus time (C-T) and capacitance versus voltage (C-V) measurements. The films were exposed to a solution of 0.1M NaCl physiological saline and preliminary results showed that the...
Early skin cancer detection with the help of dermoscopic images is becoming more and more important. Previous methods generally ignored the spatial relation of the pixels or regions inside the lesion. We propose to employ a graph representation of the skin lesion to model the spatial relation. We then use the graph walk kernel, a similarity measure between two graphs, to build a classifier based on...
Sensing and wireless technologies have made remarkable advance recently, so wireless vital sensors for medical use, which are light-weight but accurate, have been commercially available. However, because of the low reliability of the wireless data transmission, sensed vital data are often lost in the wireless channel and this is a fatal drawback of the devices for continuous monitoring of patients...
It has been long recognized that there are 2 methods for inducing VF (ventricular fibrillation) with electrical currents.. These are: (1) delivering a high-charge shock into the cardiac T-wave, and (2) delivering lower level currents for 1-5 seconds. Present electrical safety standards are based on this understanding. We present new data showing a 3rd mechanism of inducing VF which involves the steps...
The objective of this work was to investigate the effect of substrate microstructure (planar versus microtubular geometry) on the extent of osteogenic differentiation of bone mesenchymal stem (BMS) cells. For laminated sheets, the BMS cell suspension was seeded on the sheets and cultured in complete osteogenic media. For laminated microtubes, the BMS cell suspension was injected in the tubes and allowed...
Gastric impedance spectroscopy has been proposed as a method of monitoring mucosal injury due to hypoperfusion and ischemia in the critically ill. During validation tests for this procedure, it was found that 60% of the measurements had errors by factors inherent to the clinical setting, indicating that some kind of automatic error detection should be incorporated to potentially avoid the loss of...
Features are extracted from PET images employing exploratory matrix factorization techniques such as nonnegative matrix factorization (NMF). Appropriate features are fed into classifiers such as a support vector machine or a random forest tree classifier. An automatic feature extraction and classification is achieved with high classification rate which is robust and reliable and can help in an early...
Electrocardiographic T wave peak-to-end interval (TpTe) is one parameter of T wave morphology, which contains indicators for hypoglycaemia. This paper shows the corrected TpTe (TpTec) interval as one of the inputs contributing to detect hypoglycaemia. Support vector machine (SVM) and fuzzy support vector machine (FSVM) utilizing radial basis function (RBF) are used as the classification methods in...
Bone is a strongly heterogeneous natural composite with microstructure. Although the classical theory of linear elasticity has been largely used in bone ultrasonic studies, it cannot sufficiently describe the mechanical behavior of materials with microstructure. Furthermore, this theory predicts non-dispersive behavior of Rayleigh waves, which is in conflict with experimental observations. By using...
Fusion classifiers with diverse components (classifiers or data sets) outperform those with less diverse components. Determining component diversity, therefore, is of the utmost importance in the design of fusion classifiers which are often employed in clinical diagnostic and numerous other pattern recognition problems. In this paper, a new pairwise diversity-based ranking strategy is introduced to...
This paper presents a new methodology of feature extraction of sleep and wake stages of a freely behaving rat based on Continuous Wavelet Transform (CWT). The automatic separation of those stages is very useful for experiments related to learning and memory consolidation since recent scientific evidence indicates that sleep is strongly involved with offline reprocessing of acquired information during...
Current trends in healthcare technology include mobile-based applications. Relevant advances in the integration of vital signs monitoring devices with mobile platforms are widely reported nowadays. In this context, conceiving and designing an interoperable application is essential due to the growing necessity of integrating a huge and heterogeneous amount of biomedical data, coming from a wide range...
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