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A novel algorithm is presented for classification of four patterns of diffuse lung disease: normal, emphysema, honeycombing and ground glass opacity, on the basis of textural analysis of high resolution computed tomography (HRCT) lung images. The algorithm incorporates scale-space features based on Gaussian derivative filters and multi-dimensional multi-scale features based on wavelet and contourlet...
This study presents a simple decision-support system for the detection of tic events during the Tourette Syndrome (TS). The system is based on a triaxial accelerometer placed on the patient's trunk. TS is a neurological disorder that emerges during childhood and that is characterized by a large spectrum of involuntary/compulsive movements and sounds. 12 subjects with chronic TS participated in the...
The present work introduces a new ECG delineator, based on the Phasor Transform, which is characterized by its robustness, low computational cost and mathematical simplicity. The method converts each instantaneous ECG sample into a phasor, thus being able to deal very precisely with P and T waves, which are of notably lower amplitude than the QRS complex. Initially, the method relies on the detection...
We present a technique for automatic diagnosis of malignant melanoma based exclusively on local pattern analysis. The technique relies on local binary patterns in small sections in the image, and automatically selects the relevant texture features from those that discriminate best between benign and malignant skin lesions. The classification is performed using support vector machines, and the feature...
Most of the studies on the synchronization between EHG signals, recorded during the same contractions at different locations, are limited to the use of only two channels. Multichannel techniques have however been widely applied to EEG signals but rarely to EHG. In this paper, we investigate the use of multichannel uterine EMG signals for classifying contractions. We compare the performance of phase...
The paper presents methodology of a complex model reduction to its simpler version - an identifiable inverse model. Its main tool is a numerical procedure of sensitivity analysis (structural and parametric) applied to the forward linear equivalent designed for the conditions of interrupter experiment. Final result - the reduced analog for the interrupter technique is especially worth of notice as...
Limitations of the standard urogynecological pressure transducers have not adequately provided reliable measurements of intra-abdominal pressure (IAP) during physical activities. A previous novel intravaginal pressure transducer (IVT) was developed in order to overcome the shortcomings in existing technology. The design of the IVT was validated though comparisons with existing pressure transducers...
In this paper, we present a classification method of dermoscopy images between melanocytic skin lesions (MSLs) and non-melanocytic skin lesions (NoMSLs). The motivation of this research is to develop a pre-processor of an automated melanoma screening system. Since NoMSLs have a wide variety of shapes and their border is often ambiguous, we developed a new tumor area extraction algorithm to account...
Hypoglycaemia is a serious side effect of insulin therapy in patients with diabetes. We measure physiological parameters (heart rate, corrected QT interval of the electrocardiogram (ECG) signal) continuously to provide early detection of hypoglycemic episodes in Type 1 diabetes mellitus (T1DM) patients. Based on the physiological parameters, an evolved fuzzy reasoning model (FRM) to recognize the...
An LMS-based algorithm to monitor fetal and maternal heart rate in real time was implemented and evaluated on a development platform. Hardware has three modules: dsPIC30F digital signal controller, a low-noise analog front end and a storage stage. They were evaluated using on-chip debugging tools and a patient simulator. Algorithm performance was tested using simulation tools and real data. Other...
The cardiac magnetic resonance (CMR) images from a group of patients with myocardial scars and implanted cardioverter-defibrillator (ICD) are divided into a group with low risk of arrhythmias (late incidents) and a group with high risk of arrhythmias (early incidents). Several hundred quantitative features describing sizes, statistics and textures of the segmented and defined areas of the images are...
Developing countries have a large population of children living with undiagnosed heart murmurs. As a result of an accompanying skills shortage, most of these children will not get the necessary treatment. The objective of this paper was to develop a decision support system. This could enable health care providers in developing countries with tools to screen large amounts of children without the need...
Leprosy is an infectious disease caused by Mycobacterium Leprae, and generally compromises neural fibers, leading to the development of disabilities. These limit daily activities or social life. In leprosy, the study of disability considered functional (physical) and activity limitations; and social participation. These are measured respectively by EHF and SALSA scales; by and PARTICIPATION SCALE...
Detachment of greater trochanter (GT) is generally associated with hip arthroplasty complications and needs for repositioning and fixation. A new GT reattachment system (Y3) was proposed to reduce GT displacements in anterior-posterior direction to decrease non-union issues. The goal of this study is to develop and validate a FEM of the Y3 GTR system. FEM validation suggests a good concordance between...
Interdisciplinary research towards integrated systems and their applications based on emerging convergence of information & communication technologies, micro-nano and bio technologies is expected to have a direct impact in healthcare, ageing population and well being. Micro-Nano-Bio Systems (MNBS) research and development activities under the European Union's R&D Programs, Information &...
Several algorithms are available to quantify nystagmus beats in electro nystagmography (ENG) and video-oculography (VOG) recordings. These algorithms use parameterized approaches to detect the fast components of nystagmus beats. This paper proposes a wavelet approach to detect fast components of nystagmus beats. The main advantage of this approach compared to alternatives, is the completely unsupervised...
A 1.8-mW, 18.5-mm2 64-channel current readout ASIC was implemented in 0.18-μm CMOS together with a new calibration scheme for silicon nanowire biosensor arrays. The ASIC consists of 64 channels of dedicated readout and conditioning circuits which incorporate correlated double sampling scheme to reduce the effect of 1/f noise and offset from the analog front-end. The ASIC provides a 10-bit digital...
Real signals are often corrupted by noise. In applications where the noise power spectrum is variable with time, dynamic noise estimation and compensation can potentially improve the performance of signal processing algorithms. One such application is scalp EEG monitoring in epilepsy, where the electrical activity generated by cranio-facial muscle contraction and expansion, often obscures the measured...
This study investigated the usefulness of the very low spectral content of single-channel airflow recordings to help in the diagnosis of the obstructive sleep apnea (OSA) syndrome. Additionally, we evaluated whether airflow frequency components in the 0.01 - 0.10 Hz band are linked with desaturations in blood oxygen saturation (SaO2) recordings due to apnea events. The relationship between changes...
Experimental studies of pro-arrhythmic mechanisms are scarcely performed in humans due to the limited availability of human cardiomyocytes. Subsequently, extrapolation of animal experimental research to humans is widely extended. Our aim is to systematically compare the ionic mechanisms of the main cellular biomarkers of arrhythmic risk between human and rabbit using computer simulations. For this...
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