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Small calibre (<;;6mm) polytetrafluoroethylene (PTFE) bypass grafts have poor medium and long term patency due to the development of neointimal hyperplasia at the distal anastomosis. The inelasticity of PTFE is implicated in this mechanism of failure. We have developed a novel polyhedral oligomeric silsesquioxane (POSS) nanocage incorporated into a poly(carbonate)urethane (PCU) biomaterial with...
There is a considerable need for alternatives to the autologous vein and artery tissues used for vascular reconstructive surgeries such as CABG, lower limb bypass, arteriovenous shunts and repair of congenital defects of the pulmonary outflow tract. So far, synthetic materials have not matched the efficacy of native tissues, particularly small diameter applications. We have developed a completely...
We proposed a novel laser-driven short-term heating angioplasty to realize restenosis-suppressive angioplasty for peripheral artery disease. In this study, we investigated the chronic intimal hyperplasia formation after the short-term heating dilatation in vivo, as well as the thermal damage calculation on arterial smooth muscle cells (SMCs). The prototype short-term heating balloon catheter with...
We investigated the influences on the smooth muscle cells of temporally heated arterial walls in both ex vivo and in vitro study to determine the optimum heat parameter of novel short-term thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA). Arterial heating dilatation was performed by the prototype PTDBA balloon ex vivo. We found that the smooth muscle cells in the vessel wall were...
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