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A new SVD-Krylov based method is proposed, which is equivalent to compute an equality constrained leastsquares problem. The reduced model matches the first r + i Markov parameters of the full order model. Based on the rational equality constrained least-squares method, an iterative algorithm for H2 model reduction is prensented. Moreover, both algorithms of IRKA ( An Iterative Rational Krylov Algorithm)and...
Single ion channel signal of cell membrane is a stochastic ionic currents in the order of picoampere (pA). Because of the weakness of the signal, the background noise always dominates in the patch-clamp recordings. The threshold detector is traditionally used to eliminate noise and restore the single channel signal. However, this method cannot work satisfactorily when signal-to-noise ratio is lower...
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