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Detemir that a 14-C fatty acid chain is attached to position B29 of DesB30 human insulin is a soluble insulin analog developed to ensure appropriate basal insulin supply. PEGylation is one way to prolong the time of insulin action. In this study methyl polyethylene glycol succinimidyl propionate (mPEG-SPA )was used as substitutes for 14-C fatty acid to modify the DesB30 human insulin. We will show...
Various phthalates are used extensively as plasticizers in kinds of consumer products. They are harmful for human reproduction and fertility. Mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of di-(2-ethylhexyl) phthalate(DEHP),which is most commonly used as a plasticizer and solvent in numerous consumer products. MEHP has been demonstrated to be a reproductive toxicant in rodents, but...
This work investigated the potential use of benzoic acid (BA)-based immunoadsorbent, a hydrophobic adsorbent, for autoantibodies selective adsorption therapy. The adsorbent was assessed through chromatographer and batch system assays in terms of adsorption capacity, selectivity for both polycloneantibodies in normal human plasma and pathogenic antibodies in patients' sera. For human immunoglobulin...
In order to explore the possibility of inhalation of formaldehyde on mouse bone marrow cells have an impact on cell cycle and use SPF level purely Kunming male mice for the study, with a concentration of 0.5 mg /m3, 1.0 mg/m3 and 3.0 mg/m3 of gaseous Formaldehyde dynamics in mice exposed to continuous 72 hours after the exposure using flow cytometry analysis cells from mouse bone marrow cells, cell...
Cystathionine β-synthase deficiency is an inborn error of metabolism that is biochemically characterized by severe hyperhomocysteinemia and homocystinuria. Numerous cystathionine β-synthase mutants have so far been found in patients with cystathionine β-synthase deficiency. In this study, we use the cross-impact analysis to model the cystathionine βsynthase mutants with their clinical endpoints, and...
Photosensitization of quantum dots was activated with a LED light source (410nm) delivered at 5mw/cm2 to give a different dose by altering the radiation period. Cellular proliferative activity and apoptosis was measured using the cell counting kit-8 (CCK-8) assay. After four hours following photodynamic treatment, the degree of apoptosis was significantly increased, and the best experimental parameters...
Purpose: Mouse double minute 2 (MDM2) is a key negative regulator of the p53 activity. Recently, a polymorphism in the intronic promoter, SNP309, was shown to influence MDM2 expression and p53 activity. We examined whether the SNP309 was related to the risk of developing cervical cancer among Chinese populations. Experimental Design: We genotyped the MDM2 polymorphism SNP309 of peripheral blood DNA...
Human Coagulation Factor IX (hFIX) plays a crucial role in the process of human endogenous blood clotting. Patients with deficiency of hFIX will suffer from hemophilia B. In this study, we use Pichia Pastoris to produce recombinant hFIX to cure hemophilia B Human liver hFIX cDNA were amplified by RT-PCR and inserted into pPIC9k vector, to construct pPIC9k-hFIX. The pPIC9k-hFIX were integrated into...
The directly rapid determination method and the optimal analysis model of hemoglobin (HGB) in human whole blood were established by using the Fourier transform infrared spectroscopy (FTIR) and attenuated total reflection (ATR) technology. Based on the prediction effect of single wavenumber linear regression model, a wavenumbers selection method of FTIR/ATR spectroscopy analysis was developed. 20 single...
Phthalates are widely used in industry as solvents, additives and plasticizers. Some phthalates and their monoester metabolites are known to cause carcinogenic, toxic or endocrine-modulating effects. Chorion tissues as human early embryo are the base of organogenesis. Embryo (3-8 weeks) is sensitive period of teratogensis. With the development of industrialization, in addition to genetic factors,...
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