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We demonstrate here for the first time potential applicability of coherent anti-Stokes Raman spectroscopy (CARS) for protein folding and crystallization in microchannels.
We present a simple, compact, microfluidic system that easily facilitates diode laser bar optical trapping for cell stretching measurements and particle sorting within flowing microfluidic systems for the first time.
A new configuration was designed and tested based on ldquosandwichingrdquo target analyte molecules between two metal nanostructure substrates using surface enhanced Raman scattering (SERS), which exhibits significantly higher SERS enhancement compared to just one substrate.
By combining incoherent time gating (sum-frequency mixing) with coherent gating (optical coherence tomography), we process light backscattered from a sample in the optical domain to improve imaging contrast by 29 dB.
Plasmon resonances in the transmission spectrum of a tilted Bragg grating in gold coated fibers are used to detect the binding of thiolated single stranded DNA and the further binding of the complementary target DNA.
An all-fiber capillary electrophoresis system is presented. It enables sensitive in-line electrophoresis separation and fluorescence detection. As a proof of concept, a biological sample (FITC-BSA) is electrokinetically separated and analyzed.
A nanometre scale, picoNewton force probe based on advanced optical tweezers control of transparent microstructures will be presented. The probe will be applied to dynamic bio-molecular interactions in solution
The potential of biomolecular microarrays on glass for high-throughput kinetics assays has not previously been fully exploited. We demonstrate real-time label-free optical detection of antibodies binding to drug-antigen microarrays using oblique-incidence reflectivity difference (OI-RD) microscopes.
Molecular interferometric imaging (MI2) approaches the single-molecule limit for label-free direct optical detection. It is simpler, cheaper and more sensitive than surface plasmon resonance for dynamic studies of molecular interactions.
We demonstrate second-harmonic-generation (SHG) microscopic imaging on the polyhedral inclusion bodies (PIB) of nucleopolyhedrovirus in living cells. Due to a body-centeredcubic arrangement of polyhedrin trimers, these PIBs generate SHG with polarization anisotropy.
The full evolution of a filament is explored experimentally and numerically and a standardized definition is proposed. This is followed by discussing challenges in filamentation nonlinear optics and remote sensing of chem-bio agents.
We show that the selective excitation of vibrational mode is achieved by a single broadband pulse to focus its bandwidth into a narrow spectral region. The spectral focusing is performed by controlling the spectral phase.
A SPR biosensor array based on optoelectronic platform has been developed. Using integrated photodetector, the SPR signal has been directly converted into electrical signal and the device has the potential of high throughput measurement capabilities.
We describe a novel scanning optical microscope that enables high-throughput label-free detection of end-points and kinetics of multiple biomolecular reactions on microarrays with more than 10,000 protein or small-molecule targets.
The use of DC electrokinetics can ensure a uniform and pure translational motion of biological samples in an optofluidic microscope. Its ability to image a single ellipsoidal cell, Chlamydomonas, was demonstrated on-chip.
We demonstrate Fourier transform coherent anti-stokes Raman scattering (FTCARS) microscopy and show that an external field combined with the signal can overcome detector dark noise. We discuss conditions for obtaining shot-noise-limited detection and compare the S/N of FTCARS with other methods.
We developed a total internal reflection fluorescence lifetime imaging microscope to perform functional imaging of living cells membranes labeled with FRET couples. Forster resonance energy transfer efficiency can thus be followed with subwavelength axial resolution.
Imaging of a nanoscale emitter naturally provides position information beyond the diffraction limit. We use active control to switch single fluorophores on and off to image structures with 40-nm resolution in a living cell.
We theoretically and experimentally demonstrate a compact silicon photonic crystal microcavity sensor capable of detecting in vivo a single particle of size comparable to a virus.
Femtosecond stimulated Raman spectroscopy is a new time-resolved vibrational technique that enables the recording of high resolution (10-20 cm-1) vibrational spectra of dynamic and reactive chemical and biological systems with < 50 fs time resolution.
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