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This paper considers the problem of finding global states incoming to a specified global state in a Boolean network, which may be useful for pre-processing of finding a sequence of control actions for a Boolean network and for identifying the basin of attraction for a given attractor. We show that this problem is NP-hard in general along with related theoretical results. On the other hand, we present...
DNA copy number aberrations are characteristic of many genomic diseases including cancer. Microrray-based comparative genomic hybridization (aCGH) is a recently developed high-throughput technique to map and detect DNA copy number (DCN) aberrations. Unfortunately, the observed copy number changes are corrupted by noise, making aberration boundaries hard to detect. They may have false positive or may...
Show by Cheng and Church to be an NP-complex problem, biclustering algorithms are more complex than the classical one dimensional clustering technique, particularly requiring multiple computing platforms for large and distributed datasets. In this study, we proposed and extension of the robust biclustering algorithm (RoBA) that is capable of performing biclustering on extremely large or geographically...
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