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In this study, basing on electrochemistry and MEMS technology we develop a novel biosensor with multi channels to detect three markers (hyaluronic acid (HA), Laminin (LN), type IV collagen (IV-C) ) so as to evaluate the liver disease. With MEMS technology, a chip including a CE, a RE and 6 gold electrodes is fabricated for detection of at most 6 markers simultaneously. Different antibodies of serum...
The paper presents an integrated automatic micro reverse transcription polymerase chain reaction (RT-PCR) system for molecular diagnosis. The developed system can detect viruses with a high sensitivity and specificity using antibody-conjugated superparamagnetic beads. The target viruses were first captured by conjugated antibodies on the magnetic beads and then attracted by a magnetic field generated...
Magnetic nanoparticles would be one of the efficient tools for the improvement of antibody-antigen reaction and the enhancement of detection signal for immunofluorescence assay (IFA). This paper focuses on the investigation of the immuno functionality of antibodies immobilized on the surface of iron oxide nanoparticles. Fe3O 4 superparamagnetic nanoparticles were successfully produced and conjugated...
ATP synthase is the minimal molecular motor and a highly efficient rotary machine. Giant magnetoresistance (GMR) effect is the change in electrical resistance that occurs when materials are exposed to a magnetic field. In this paper, a new dynamic biomolecule identification technique is proposed using GMR sensor combined with ATP molecular motors. Molecular motors, attached with magnetic nano-particles,...
The bio-heat transfer problem and the thermal ablation in bio-tissue require general solutions for the control of the external heating power. An algorithm based on the molecular dynamics (MD) and the GROMACS protein data bank is developed to solve the bio-heat transfer problem. The value of the thermal conductivity of alanine is calculated from the autocorrelation function of the Green-Kubo formalism...
The new gel-immobilization method for preparing a single stranded DNA (ssDNA) template has been described for single nucleotide polymorphisms (SNPs) genotyping by bioluminometric assay based on allele-specfic extension reaction. In this method, PCR products amplified by a primer modified with acrylamide group at the 5'-terminal is copolymerized with acrylamide monomer to form gel. After the ssDNA...
A micro-pillar chip is proposed and developed to separate the amino acids, phenylalanine and tryptophan, through the aqueous two-phase system (ATPS). The surface properties of micro-pillars, specifically hydrophobicity and hydrophilicity for separation are also investigated. Because their isoelectric points (pI values) are similar, these amino acids are difficult to separate by general extraction...
Ideally the atomic force microscope (AFM) provides three-dimensional structure of surfaces at high resolution. Nevertheless, there are some requirements for work with biological specimens which should be taken into consideration in the design of an AFM. And a key requirement is that the AFM should be capable of scanning over relatively large areas. In this paper we introduce an experimental AFM head...
The objective of this paper is to study the therapeutic effect of nanosized As2O3/Fe3O4 complex (Fe3O4 magnetic nanoparticles containing As2O3) combined with magnetic fluid hyperthermia (MFH) on human cervical cancer Hela cells in vitro and xenograft cervical cancer in nude mice. The growth and apoptosis of Hela cells treated with nanosized As2O3/Fe3O4 complex combined with MFH was examined by MTT,...
Attempts to develop effective and low cost techniques for blood screening and detection of hemoglobin have become very important. In this work, a home-made biosensor for rapid detection of hemoglobin has been proposed and established on the basis of the reaction of hemoglobin and potassium ferricyanide and the spectral absorption/reflection principle. Using the fast evaporation technique, the reaction...
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