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The following topics are dealt with: protein-protein interaction; cancer informatics; disease informatics; protein folding; gene networks; biosequence analysis; biochemical modeling; microarray analysis; biological theory; medical informatics; RNA structure; and RNA function
Microarray technology has previously been used to identify differentially expressed genes between tumor and normal prostate samples in a single study as well as in a synthesis involving multiple studies. When integrating results from several Affymetrix microarray datasets, previous studies have used probeset-level data which may lead to a loss of information contained at the probe-level. Here, we...
The advanced protein profiling technologies can simultaneously resolve and analyze multiple proteins. Evaluating multiple proteins will be essential to establish signature proteomic patterns that distinguish cancer from non-cancer. It is desirable to have complex and intelligent analytical tools to detect the changes in protein expression and their correlation to diseases conditions. This paper proposed...
Ovarian cancer recurs at the rate of 75% within a few months or several years later after therapy. Early recurrence, though responding better to treatment, is difficult to detect. Recently, high-resolution MALDI-TOF (matrix-assisted laser desorption/ionization time-of-flight) mass spectrometry has shown promise as a screening tool for detecting discriminatory protein patterns. The major computational...
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