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Electric field mediated drug and gene delivery is a novel method that uses pulsed electric fields to improve permeability of cell membranes and therefore desired agent uptake by tissues. In this paper, we describe the modeling and experimental proof of concept of a method to direct electric fields to subsequently focus drug or gene uptake at a desired site. The in vitro experimental results presented...
Electroporation, the permeabilization of the cell membrane with electrical pulses, is being used for in vivo gene therapy, drug therapy and minimally invasive tissue ablation. Applying electrical pulses across cells can have a variety of outcomes; from no effect to reversible electroporation to irreversible electroporation. For reliable in vivo use of electroporation it is important to have real time...
A miniaturized system for sample preparation of relevant bacterial pathogens has been developed using a variety of microfabrication techniques. The system manipulates and disrupts Eschericha coli bacterial cells using dielectrophoresis, electroporation and enzymes. The microchip consisted of circular gold electrodes patterned on glass using standard photolithography housed in a PDMS chamber. The bacterial...
Opto-Plasmonic Tweezers are proposed as a new optical manipulator and rotator for biological cells. The approach utilizes polarized light to excite localized surface plasmon resonance (LSPR) on an array of Au nanostructure. Large dielectrophoretic trapping force is expected to be induced by the highly non-uniform scattering field from the resonant oscillating dipoles. Fine orientation control of the...
A miniaturized system for sample preparation of relevant bacterial pathogens has been developed using a variety of microfabrication techniques. The system manipulates and disrupts Eschericha coli bacterial cells using dielectrophoresis, electroporation and enzymes. The microchip consisted of circular gold electrodes patterned on glass using standard photolithography housed in a PDMS chamber. The bacterial...
Electric field mediated drug and gene delivery is a novel method that uses pulsed electric fields to improve permeability of cell membranes and therefore desired agent uptake by tissues. In this paper, we describe the modeling and experimental proof of concept of a method to direct electric fields to subsequently focus drug or gene uptake at a desired site. The in vitro experimental results presented...
Electroporation, the permeabilization of the cell membrane with electrical pulses, is being used for in vivo gene therapy, drug therapy and minimally invasive tissue ablation. Applying electrical pulses across cells can have a variety of outcomes; from no effect to reversible electroporation to irreversible electroporation. For reliable in vivo use of electroporation it is important to have real time...
Opto-Plasmonic Tweezers are proposed as a new optical manipulator and rotator for biological cells. The approach utilizes polarized light to excite localized surface plasmon resonance (LSPR) on an array of Au nanostructure. Large dielectrophoretic trapping force is expected to be induced by the highly non-uniform scattering field from the resonant oscillating dipoles. Fine orientation control of the...
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