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Platelet-rich plasma (PRP) has been gaining increasing popularity in orthopedics and oral and maxillofacial surgery because of its potential efficacy in enhancing bone regeneration. To maximally augment bone healing using PRP and to control the bioavailability of the relevant growth factors, we have designed an alginate hydrogel-based PRP-delivery system. The bioactivity of the growth factors released...
Autofocusing is a fundamental procedure towards automated microscopic evaluation of blood smear and pap smear samples for clinical diagnosis. This paper presents comparison results of 16 focus algorithms based on a total of 8000 bright-field images from 10 blood smear and pap smear samples. A ranking methodology adapted from our previously proposed ranking system is used for thoroughly evaluating...
Susceptibility-weighted magnetic resonance imaging is a powerful tool for high resolution imaging of the vasculature, aiding in the diagnosis of many pathologic conditions. The technique is especially beneficial at higher field strengths where traditional sequences that measure cerebral blood volume suffer from severe distortions, rendering them inapplicable at 7 T. However, conventional susceptibility-weighted...
Though myocardial viscoelasticity is essential in the evaluation of heart diastolic properties, it has never been noninvasively measured in vivo. By the ultrasonic measurement of the myocardial motion, we have already found that some pulsive waves are spontaneously excited by aortic-valve closure (AVC) at end-systole (T0) (IEEE UFFC-43(1996)791-810). Using a sparse sector scan, in which the beam directions...
Total hemoglobin (tHb), carboxyhemoglobin (COHb), and methemoglobin (MetHb) are usually measured with a CO-oximeter. Noninvasive and continuous measurement of these blood components is expected to decrease the pain of a patient. Therefore, we developed an instrument to measure oxygen saturation (SpO2), tHb, COHb, and MetHb non invasively. Multiwavelength LED (600, 625, 660, 760, 800, 940, and 1300...
In this study, the physiological parameters such as extracellular (SAGM+CPD+residual plasma) Na+, K+, Cl-, pH, 2,3-DPG and ATP together with the Cole-Cole parameters were measured using erythrocyte suspensions from 51 male donors (31 donors form the training set and 20 donors are used for testing), on the 0th, 10th, 21st, 35 th and 42nd days of storage. Accordingly, electrical parameters were all...
Algorithms for real-time ambulatory monitoring of physiological signals often run on platforms which have very limited processing power and memory. Therefore, in addition to functionality, it is necessary to carefully consider real-time performance requirements. This is particularly important for physiological monitoring of life threatening conditions such as hemorrhage. In this paper we present a...
In functional magnetic resonance imaging (fMRI), the cerebral blood volume (CBV) based approach with exogenous contrast agent has been found to have better spatial specificity than the widely applied blood oxygenation level-dependent (BOLD) method. Recently, an endogenous CBV-based contrast, vascular space occupancy-dependent (VASO) technique, was developed for human research. However, the spatial...
A new system for measuring the oxygen saturation of blood within tissue has been developed, for a number of potential patient monitoring applications. This proof of concept project aims to address the unmet need of real-time measurement of oxygen saturation in the central nervous system (CNS) for patients recovering from neurosurgery or trauma, by developing a fiber optic signal acquisition system...
An accurate and rapid assay of cardiac nerve growth factor (NGF) levels in blood can provide physicians with critical information regarding myocardial injury and neural remodeling in cardiac tissues to identify patients at risk of impending heart attack, thereby enabling them to receive appropriate lifesaving treatment more quickly. Currently used assay methods, such as enzyme-linked immunosorbent...
Measurement of oxygen saturation levels in blood is a vital activity during most medical treatments. A pulse oximeter is a device most commonly used to perform this measurement. It provides convenient, non-invasive and continuous monitoring of oxygen levels in a human body. However, it is often a tedious task to select the appropriate hardware and software components to manufacture a pulse oximeter...
A mixed meal model was developed to capture the gut absorption of glucose, protein, and free fatty acid (FFA) from a mixed meal into the circulatory system. The output of the meal model served as a disturbance to the extended minimal model [3], which successfully captured plasma FFA, glucose and insulin concentration dynamics and interactions. A model predictive controller (MPC) was synthesized to...
We recently introduced an imaging application combining dynamic positron emission tomography (PET), a modification of the two-tissue compartment model, and constrained parameter estimation. The objective of this method, which we have called neurotransmitter PET (ntPET), is to estimate the timing of neurotransmitter (NT) kinetics. The time course of NT release in response to drugs or other stimuli...
ST-segment depression in epicardial electrograms can be a "reciprocal" effect of remote myocardial ischemia (MI), and can also be due to local partial-thickness or "subendocardial" MI. Experimental studies have shown either ST elevation or depression in leads overlying a subendocardial ischemic region. Those reporting elevation have shown depression over the lateral borders of...
A promising procedure combining dielectric spectroscopy of red blood cells and an inverse application of an effective medium theory (EMT) has been realized to prove the plausibility to obtain cells morphological information. This theoretical-experimental methodology could be the basis for an accurate and simple tool in diagnosis and research activity, especially when cell morphological alterations...
Oximetry is a common blood monitoring technique, useful for the assessment of blood flow and blood oxygen saturation information. Commercial oximeters generally utilize an optical transmission measurement scenario which necessitates the use of wavelengths residing in the optical absorption window (650-1100 nm) which are capable of traveling long distances before absorption. When the source and detector...
The brain response to temporal frequencies (TF) has been already reported, but with no study for different TFs with respect to various spatial frequencies (SF). Functional Magnetic Resonance Imaging (fMRI) experiments were performed by 1.5 Tesla General Electric-system in 14 volunteers (9 males and 5 females, range 19-26 years) during square-wave reversal checkerboard visual stimulation with different...
Miniaturised point-of-care cardiac marker sensors are being developed, based on impedimetric sensing of cardiac enzyme capture by an antibody layer immobilised on a planar gold electrode sensor. Gold/Ti-on-glass substrates have been used, in a 2 electrode configuration, with antibodies immobilised on the working electrode. Microfluidic structures have been fabricated by a CO2 laser, in 25 mum thick...
In functional magnetic resonance imaging (fMRI), the cerebral blood volume (CBV) based approach with exogenous contrast agent has been found to have better spatial specificity than the widely applied blood oxygenation level-dependent (BOLD) method. Recently, an endogenous CBV-based contrast, vascular space occupancy-dependent (VASO) technique, was developed for human research. However, the spatial...
Algorithms for real-time ambulatory monitoring of physiological signals often run on platforms which have very limited processing power and memory. Therefore, in addition to functionality, it is necessary to carefully consider real-time performance requirements. This is particularly important for physiological monitoring of life threatening conditions such as hemorrhage. In this paper we present a...
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