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Genome-wide association study for complex diseases will generate massive amount of single nucleotide polymorphisms (SNPs) data. Univariate statistical test (i.e. Fisher exact test) was used to single out non-associated SNPs. However, the disease-susceptible SNPs may have little marginal effects in population and are unlikely to retain after the univariate tests. Also, model-based methods are impractical...
The time interval between the aortic (A2) and pulmonary (P2) components of the second heart sound (S2) is an indicator of the presence and severity of several cardiac abnormalities. However, in many cases identification of the A2 and P2 components is difficult due to their temporal overlap and significant spectral similarity. In this work, we present a method to extract the A2 and P2 components from...
It is estimated that over 200 million people worldwide have osteoporosis. The prevalence of osteoporosis is continuing to escalate with the increasingly elderly population. The major complication of osteoporosis is an increase in fragility fractures leading to morbidity, mortality, and decreased quality of life. This investigation aimed at profiling the incidence and risk of osteoporosis in adult...
We have commonly employed medical images, not including X-ray photography, which have their image enhanced by taking advantage of certain characteristics of the human body to look for some valuable medical information. In general, the medical imaging modalities have employed an image acquisition method which enhances a certain feature of the seat of a disease for later processing of the acquired images...
A new and complementary method to assess image quality is presented. It is based on the comparison of the local variance distribution of two images. This new quality index is better suited to assess the non-stationarity of images, therefore it explicitly focuses on the image structure. We show that this new index outperforms other methods for the assessment of image quality in medical images
Despite much progress and research, fully reliable computer based epileptic seizure detection in EEG recordings is still elusive. This paper outlines a new strategy toward seizure detection. It is proposed that it is not the precise nature of a statistic that is important, but rather its variance over time. Using this, algorithms are presented that are able to successfully identify 97.6% of seizures...
Catheter-based epicardial mapping is possible with two access methods: transthoracic access and transvenous access. Transthoracic access requires lengthy sequential mapping procedures and stable arrhythmias. Transvenous access uses the multielectrode (4-to-20 electrodes) catheters placed in the coronary veins, however, leaves most of the epicardium inaccessible to direct measurement. The aim of this...
The aim of the present study was to test the hypothesis that the fracture strength of calcium hydroxide and mineral trioxide aggregate (MTA) filled immature teeth decrease over time. Immature mandibular incisors from sheep were extracted and the pulps were extirpated using an apical approach with a barbed broach, and the teeth were divided into three experimental groups. Group 1: Untreated teeth....
In this paper different estimation techniques are evaluated for the assessment of electromechanical delay (EMD). The following techniques are compared for benchmarking purposes: envelope estimation and thresholding, with different subjective combinations of filters and thresholds, and a double threshold statistical detector (DTD). Performances are compared in terms of bias, standard deviation and...
In this paper, a new robust adaptive tool for new born infant cry analysis is proposed, characterised by high tracking capability, well suited for the signals under study. It performs F noise and resonance frequencies tracking, on signal frames of varying length (even few ms), adaptively tailored to varying signal characteristics. Moreover, voiced/unvoiced separation is implemented, allowing disregarding...
A statistical interpretation of existing parallel magnetic resonance imaging methods reveals that the underlying noise model is of additive independent Gaussian noise. In reality MR imaging processes suffer from a variety of noise, errors and other uncertainties. A careful statistical analysis of these uncertainties can potentially allow significant improvement of the reconstruction process. In this...
In this paper, we build a mathematical model of the whole-body neuromuscular network and identify its parameters by optical motion capture, inverse dynamics computation, and statistical analysis. The model includes a skeleton, a musculotendon network, and a neuromuscular network. The skeleton is composed of 155 joints representing the inertial property and mobility of the human body. The musculotendon...
We consider computationally reconstructing gene regulatory networks on top of the binary abstraction of gene expression state information. Unlike previous Boolean network approaches, the proposed method does not handle noisy gene expression values directly. Instead, two-valued "hidden state" information is derived from gene expression profiles using a robust statistical technique, and a...
This paper investigates the effect of subject's age on Web-safe color visibility on a white background. An evaluation of Website accessibility is necessary because of the rapid dissemination of information on the World Wide Web. One important factor to be considered when developing accessible Websites is the foreground color and the background color combination. In this study, the visibility of 21...
This paper presents a complete open software environment for control, data processing and assessment of visual experiments. Visual experiments are widely used in research on human perception physiology and the results are applicable to various visual information-based man-machine interfacing, human-emulated automatic visual systems or scanpath-based learning of perceptual habits. The toolbox is designed...
Texture analysis of B-mode ultrasound images of carotid atheromatous plaque can be valuable for the accurate diagnosis of atherosclerosis. In this paper, two frequency-based texture analysis methods based on the Fourier Power Spectrum and the Wavelet Transform were used to characterize atheromatous plaques. B-mode ultrasound images of 10 symptomatic and 9 asymptomatic plaques were interrogated. A...
For pt.I see ibid., p.Z004024-7. Stimulation of the diseased retina via an intraocular electrode array is a proposed means of restoring some vision to the profoundly blind. A prosthetic device to this end would involve post-implantation calibration (analogous to cochlear implant fitting), wherein the subject indicates those discrete positions in the visual field where luminous percepts are elicited...
It has been shown that remote monitoring of pulmonary activity can be achieved using ultra-wideband (UWB) systems, which shows promise in home healthcare, rescue, and security applications. In this paper, a geometry-based statistical channel model is developed for simulating the reception of UWB signals in the indoor propagation environment. This model enables replication of time-varying multipath...
The multiple component synchrony measure (MCSM), a multivariate objective response detection (MORD) technique in the frequency domain, was applied to EEG signals during somatosensory stimulation of the right posterior tibial nerve collected from derivations [Fpz'-Cz'] and [C3'-C4'] of 10 adult volunteers. Stimuli were applied at the rate of 4.91 Hz and at the motor threshold intensity level. Detection...
Nonlinear processes of the autonomic nervous system (ANS) can produce breath-to-breath variability in the pattern of breathing. In order to provide assess to these nonlinear processes, nonlinear statistical dependencies between heart rate variability and respiratory pattern variability are analyzed. In this way, auto-mutual information and cross-mutual information concepts are applied. This information...
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