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In this note, we present an approach for developing patient-specific 3D models of portal veins to provide geometric boundary conditions for computational fluid dynamics (CFD) simulations of the blood flow inside portal veins. The study is based on MRI liver images of individual patients to which we apply image registration and segmentation techniques and inlet and outlet velocity profiles acquired...
A new magnetic field mapping method in MRI is presented. This technique is ideal for severe inhomogeneities where plane warp cannot be ignored. The present study employs a ferromagnetic ball to create a perturbation within the imaged volume. The magnetic moment and position of the device are acquired experimentally with a new technique that excites magnetic equipotentials within a volume. A three...
In this note, we present an approach for developing patient-specific 3D models of portal veins to provide geometric boundary conditions for computational fluid dynamics (CFD) simulations of the blood flow inside portal veins. The study is based on MRI liver images of individual patients to which we apply image registration and segmentation techniques and inlet and outlet velocity profiles acquired...
A new and complementary method to assess image quality is presented. It is based on the comparison of the local variance distribution of two images. This new quality index is better suited to assess the non-stationarity of images, therefore it explicitly focuses on the image structure. We show that this new index outperforms other methods for the assessment of image quality in medical images
As the global Internet evolves into today's more highly mobile and broadband service offerings, it is anticipated that the applications of new services to support telemedicine and eHealth operations using these offerings will result in increasing healthcare benefits for all and generally a lower cost. The one concern that must be addressed when making these changes is to ensure that security technology...
EEG forward problem solution using numerical head models with the same resolution and geometry as that available from MRI is desirable. This implies dealing with realistic head models of over 2 million elements, for which problem solution has so far been impractical due to issues of computation time and memory. This paper investigates the possibilities given by high performance computing (HPC) to...
This paper presents an analysis of the effect of RF apodization for parallel spatially selective excitation in MRI. Using the small tip-angle approximation and the k-space interpretation, the analysis shows that for multidimensional multi-channel parallel excitation, limited RF pulse duration can lead to ringing excitation artifacts, similar to the truncation artifacts. Proper weighting of RF pulses...
The value of MRI in defining target volumes and organs at risk is established. Numerous difficulties appear to stand in the way of using MRI alone in dose planning, with the result that this imaging modality is used in most cases in conjunction with computerized X-ray tomography (CT). The aim of this paper is to appreciate these difficulties: geometrical distortion, chemical shifts, dosimetric accuracy...
MRI of flow remains a challenging problem despite significant improvements in imaging speeds. For periodic flow the acquisition can be gated, synchronizing data acquisition with the flow. However, this method fails to work if the flow is sufficiently fast that turbulence occurs, or when it is sufficiently fast that blurring occurs during the excitation of the spins or the acquisition of the signal...
An image registration technique based on feed forward neural network and Fourier Transform is developed and presented. In the proposed scheme, the spectrums of the acquired images are computed, the Fourier coefficients within a selected central window of each spectrum are extracted and fed as inputs to the neural network. The feed forward neural network is implemented to estimate the transformation,...
A new passive shim design method is presented which is based on a magnetization mapping approach. Well defined regions with similar magnetization values define the optimal number of passive shims, their shape and position. The new design method is applied in a shimming process without prior-axial shim localization; this reduces the possibility of introducing new errors. The new shim design methodology...
Magnetic bioassay is becoming of great interest in several application including magnetic separation, drug delivery, hyperthermia treatments, magnetic resonance imaging (MRI) and magnetic labelling. The latter can be used to localize bio-entities (e.g. cancer tissues) by using magnetic markers and high sensitive detectors. To this aim SQUIDs can be adopted, however this result in a quite sophisticated...
A new high intensity focused ultrasound (HIFU) probe has been designed and tested by using MRI. The probe is intended to be used by physicians to correct valvular dysfunction in the saphenous vein, which is known to be the cause of superficial venous insufficiency (SVI) and varicose veins. Treating SVI with HIFU is possible, since venous tissue undergoes localized partial shrinkage when subjected...
The purpose of this research was two-fold: (1) to investigate the properties of statistical shape models constructed from manually segmented cardiac ventricular chambers to confirm the validity of an automatic 4-dimensional (4D) segmentation model that uses gradient vector flow (GVF) images of the original data and (2) to develop software to further automate the steps necessary in active shape model...
In this paper, we present a novel and accurate approach for nonrigid registration. New feature descriptors are built as voxel signatures using scale space theory. These descriptors are used to capture the global motion of the imaged object. Local deformations are modelled through an evolution process of equi-spaced closed curves/surfaces (iso-contours/surfaces) which are generated using fast marching...
Mutual information (MI) has proven to be a useful similarity measure for spatial registration between related pairs of images in various medical imaging applications. Image registration algorithms that utilize the MI assume that the best alignment between a pair of images is reached when their MI is at its maximum. However, this assumption is not always valid because the MI is not only sensitive to...
Denoising is an important step for image processing. One of the most important characteristics of MRI (MRI) is the complicated changes of gray level. For MRI, preservation of useful information is more important than simple improvement of Signal-Noise Ratio (SNR). Traditional filtering algorithms are not fit for MRI. Adaptive Template Filtering Method (ATFM) can dynamically match the best template...
An absolute positioning technique has been developed for ferromagnetic markers in medical instruments and untethered devices operating in a magnetic resonance imaging (MRI) system. This technique allows high precision 3D readings of the location of the device with respect to the absolute center of the MRI bore. The local magnetic field induced by the device is used as a signature for localization...
MRI plays an expanding role in stem cell therapies. The non-invasive nature and high spatial resolution of MR imaging make MR imaging a powerful tool to investigate biologic processes at the molecular and cellular level in vivo longitudinally. Quantitative detection of stem cells after transplantation may allow assessment of stem cell localization and migration, and monitoring of the therapeutic effectiveness...
The feasibility of using 2D real-time control to navigate ferromagnetic entities in an MRI bore for novel medical interventions is assessed. Preliminary experimental results confirm that a simple PID controller can be suitable for several applications where targeting out-of-reach locations within the cardiovascular system is essential
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