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Recent advances in tissue-engineered cartilage open the door to new clinical treatments of joint lesions. Common to all therapies with in-vitro engineered autografts is the need for optimal fit of the construct, to allow screwless implantation and optimal integration into the live joint. Computer assisted surgery techniques are prime candidates to ensure the required accuracy while at the same time...
A common manifestation of osteoarthritis (OA) of the knee is the morphological degeneration of articular cartilage. In vivo magnetic resonance imaging (MRI) offers the potential to visualize and analyze quantitatively morphology such as cartilage thickness and volume. The purpose of this work was the development of new image processing techniques and application of existing ones for the intra and...
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