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A high frequency contrast-assisted destruction/reperfusion imaging system has been developed to improve image resolution in previous study. Our goal in this work is to build a fast and robust algorithm to evaluate volumetric microcirculation blood flow. The microcirculation flow rate is determined by the multiplication of perfusion area and corresponding blood flow velocity mapping. The blood flow...
A fuzzy modelling approach is being proposed in this paper to estimate the model of tumorous cerebral tissues on MRI images . According to the graduality of description of neuro-radiologists, two tables have been combined to address two types of potential categories of glioma characteristics one is the array of different tissues versus gray level, and the other is the possibility of different tissues...
To explore the characteristics of thermo-source of breast tumors on thermal texture maps. Compared with the histological results, thermo-source characteristics on TTM in 106 cases with breast mass, who would undergo breast surgery, were analyzed according to the parameters such as the depth, morphology, structure, and temperatures of abnormal heat foci in order to find the differences between benign...
This paper reported the identification and mechanism of dynamic mass redistribution in living cells mediated by epidermal growth factor receptor (EGFR) activation using resonant waveguide grating (RWG) biosensors. In response to epidermal growth factor (EGF) stimulation, human epidermoid carcinoma A431 cells gave rise to a dynamic response due to dynamic mass redistribution (DMR) in the cells. The...
Automatic contouring for breast tumors using medical ultrasound (US) imaging may assist physicians, without relevant experience, in making correct diagnoses. This study utilizes the watershed transform and active contour model (ACM) to overcome the natural properties of US images, speckle, noise and tissue-related textures, to segment the breast tumors precisely. The watershed transform is performed...
Masses due to benign breast diseases and tumors due to breast cancer present significantly different shapes on mammograms. In general, malignant tumors appear with rough and complex boundaries or contours, whereas benign masses present smooth, round, or oval contours. Fractal analysis may be used to derive shape features to perform pattern classification of breast masses and tumors. Several procedures...
Here, a filter with series of pools and dams structures was designed and fabricated, utilizing size difference between tumor and blood cells. The cell mixtures were successfully filtrated out by the filter, and separation efficiency was up to 99.9%. To evaluate the filter, physical models were made to describe the behaviors of different cells in microfluidic systems. As the ability of cell deformation...
A novel tumor detection technique on CT scan images of the neck area is detailed in this paper. This technique is based on an airways' symmetry evolution within slices. The algorithm proposes to the physician a set of three slices where a tumor (if it exists) should mostly be located. Then, he will just have to browse the three slices instead of almost 100 in a CT scan. Our method is very effective...
High intensity focused ultrasound (HIFU) is one of promising non invasive thermal ablation techniques of tumor, and the demand of imaging for guidance the HIFU procedure is becoming important. We choose ultrasound imaging method based on sequence images to locate the focal position of the HIFU. To the characteristic of ultrasound sequence images, we adopt a diffusion stick method for speckle noise...
An automated image analysis method for quantification of the size and number of lymph nodes in surgical specimens of stage II colorectal cancer is presented. The quantification is made using routine histopathologic sections of lymph nodes that have been dissected by pathologists from resection specimens. The hematoxylin and eosin stained sections on slides are imaged with a standard image scanner...
With the advancement of the imaging facility and image processing technique, computer assisted surgical planning and image guided technology have become increasingly used in neurosurgery. For MRI has the characteristic of multi-spectral image data, so knowledge-base techniques is widely used in brain MRI segmentation. Here we recognize the location of the tumor automatically and provide an accurate...
The study was designed to observe the effects of 50 Hz homogeneous ferromagnetic field (0.097 T) exposure on change of intracellular calcium-ion concentration of human low differentiation gastric adenocarcinoma cell line SNU and lymphocytes in vitro. SNU cells and human peripheral blood lymphocytes in vitro were exposed to 50 Hz homogeneous ferromagnetic field at different time periods. Cells were...
This paper describes problems in traditional transanal endoscopic microsurgery (TEM), and proposes a mechatronics approach in new design. As one of several actuation mechanisms to expose rectal cavity, a compression coil spring made of shape memory alloy (SMA) has been studied. A custom SMA spring actuator was designed to displace 12 mm with 45 N driving force. This actuator was embedded with our...
We evaluated three non-invasive method, thermography, laser Doppler imaging and near infrared multi-spectral imaging to quantitatively assess parameters of vascularity in Kaposi's sarcoma. The KS lesion generally has increased temperature, blood velocity and blood deoxy-hemoglobin. There is a strong correlation between temperature and blood velocity (R= 81, p<0.001). After treatment with experimental...
The classification of the uterine myoma and adenomyosis from their ultrasound images mainly depends on doctors' experience and lacks objective criterions. Here a novel classification method is proposed using the multiresolution analysis and the orientational fractal analysis. Firstly, texture features under various resolutions and orientational fractal features are obtained from ultrasound images...
Functional imaging has the potential to be a practical and widely-available method of studying the pathophysiology of disease using modern CT and MRI technologies. With the high temporal resolution achievable by these technologies, a two-compartment distributed-parameter model, which more accurate represents the tracer concentration within the vascular space, was applied on two patients' data with...
Microwave breast tumor detection uses the electrical property contrast between normal tissues and malignancies to detect the latter in an early development stage. However, previous works on the microwave imaging uses 2-D or more complicated models of the breast and electromagnetic wave propagation. We present a computationally efficient and physically instructive electromagnetic wave channel modeling...
We used sub-terahertz (THz) imaging to exam two cross sections of epithelial cancer tissue embedded in paraffin using a 0.19 THz electromagnetic wave. The sub-THz imaging system was constructed with a tunnel injection transit time (TUNNETT) diode, a Schottky barrier diode detector and a X-Z stage. We examined the difference between a sub-THz wave absorption in melanoma and nevus tissue
Small animal imaging systems now allow researchers to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images which are sensitive to blood volume, blood flow, and metabolic rate of oxygen. Optical tomography,...
Because of the overwhelming scattering of light in biological tissues, the spatial resolution and imaging depth of conventional fluorescent imaging is unsatisfactory. Therefore, we present a dual modality imaging technique by combining fluorescence imaging with high-resolution noninvasive photoacoustic tomography (PAT) for the study of an animal tumor model. PAT provides high-resolution structural...
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