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The cortical vascular blood flow pattern is associated with the functional response in cerebral cortex. The pattern of the vascular blood flow can be used to study the spatiotemporal activities of the somatosensory center and the diagnosis of the focal stroke or ischemia. In this present study, temporal laser speckle analysis is used to obtain the cortical blood flow information. By centerline modeling...
Microscopic imaging is an important phenotyping tool to characterize the phenotype (e.g., morphology and behavior) change caused by genotype manipulation such as mutation and gene knockout. Recently we use high resolution microscopic imaging to study the morphological change on mouse placenta induced by retinoblast (Rb) gene knockout. In order to assess the morphological change we first segment each...
Medical image security can be enhanced using watermarking, which allows embedding the protection information as a digital signature, by modifying the pixel gray levels of the image. In this paper we propose a reversible watermarking scheme which guarantees that once the embedded message is read, alterations introduced during the insertion process can be removed from the image. Thereafter, original...
To explore the characteristics of thermo-source of breast tumors on thermal texture maps. Compared with the histological results, thermo-source characteristics on TTM in 106 cases with breast mass, who would undergo breast surgery, were analyzed according to the parameters such as the depth, morphology, structure, and temperatures of abnormal heat foci in order to find the differences between benign...
The degree of hand pressure applied on a breast determines the possibilities of lump detection during breast self-examination. In this paper, a method for estimating hand pressure is presented by means of analysing image entropy for an image sequence obtained through a Web camera. This is achieved by, firstly, calculating the difference between the current and initial images followed by the entropy...
Optical methods from the near infrared range, in particular the time resolved near infrared spectroscopy offer a new non-invasive, real-time technique for monitoring of the blood perfusion and oxygenation in living tissue. The principle and instrumentation of the time resolved optical spectroscopy system for cerebral oxygenation imaging have been described. The system consists of two semiconductor...
Major function of the heart is to pump blood flow up to all tissues or organs in the body, and it is generally recognized that cardiac function under various diseased conditions are mainly represented by a relationship between blood flow and pressure inside of the heart. In this report, an original proposal of evaluation method on cardiac function is introduced through a simultaneous measurement of...
The transcutaneous fluorescent imaging (TFI) method was applied to the imaging of a small experimental animal such as a rat. The feasibility of the functional imaging in TFI was verified. To make this method more practical, a technique of scattering suppression was proposed. The depth-dependent PSF was derived as an analytical solution in a closed form. The applicability of this technique to the functional...
The decrease of accuracy in patients' repeated positioning in radiotherapy due to body's transformation is considered and a positioning error measurement method using dynamic template matching technique is brought forward in this paper. This method is an improvement of the matching method to correct positioning error based on the CT digitally reconstructed radiograph(DRR), which uses the video reconstructed...
This document describes the design and preliminary testing of a cable-driven robot for the purpose of traveling on the surface of the beating heart to administer therapy. This methodology obviates mechanical stabilization and lung deflation, which are typically required during minimally invasive cardiac surgery. Previous versions of the robot have been remotely actuated through push-pull wires, while...
It has been a goal of neuroprosthesis researchers to develop a system, which could provide artificial vision to a large population of individuals with blindness. It has been demonstrated by earlier researches that stimulating the visual cortex area electrically can evoke spatial visual percepts, i.e. phosphenes. The goal of visual cortex prosthesis is to stimulate the visual cortex area and generate...
For diagnosing the colon's pathologies micro-invasively or non-invasively actively, an autonomous prototype of the earthworm-like robot for colonoscopy was designed according with the principle of the bionics and manufactured using precision process technology. In-Vitro experiments in pig colon were made. This micro robot for colonoscopy was drove directly by electromagnetic linear driver. The mobile...
The extraction of tongue area from digital photos is essential to an automatic tongue diagnostic system in traditional Chinese medicine. Simple segmentation methods couldn't be effective due to the weak edge of tongue and the details on the tongue's surface. In this paper, we propose a unique segmentation method based on the combination of the watershed transform and active contour model (ACM). The...
An optical/potential CMOS image sensor was designed and fabricated for bioimaging applications. The image sensor is capable to simultaneously sense an optical image and an on-chip potential image. Target applications of the sensor are on-chip (optical + potential) neural imaging and on-chip DNA microarray sensing. The sensor has a QCIF (176 times 144) pixel array with alternatively aligned optical/potential...
Standard Fourier domain optical coherence tomography (FD-OCT) and line-field Fourier domain optical coherence tomography (LF-FDOCT) are described. The standard FD-OCT has the measurement speed of 36 frames/sec and one frame consisting 500 A-scans. The LF-FDOCT is an improved version of FD-OCT and determines a cross section of a sample without any mechanical scanning. The LF-FDOCT has the measurement...
Optical coherence tomography (OCT) is a new technique mainly used in biomedical imaging. Here we present a particle-fixed Monte Carlo (PFMC) simulation for OCT. The scattering particles of the sample are assumed to be temporarily fixed randomly in the simulation process of backscattering light. The new model explains the exponential decay signal at the interface of different media layers in OCT experimental...
According to the characteristics of medical image and wavelet transform, a scalable coding algorithm is presented, which can be used in image transmission by network. Wavelet transform makes up for the weakness of DCT transform and it is similar to the human visual system. The second generation of wavelet transform, the lifting scheme, can be completed by integer form, which is divided into several...
Temperature is one of the parameters which gives information about some physiological changes in the human body, especially in spinal cord injured (SCI) individuals and their rehabilitation. Exercise induces muscle contraction, and in interactivity with cardiovascular and respiratory system produces heat, which dilates by conduction through the tissue to body surface. In individuals with spinal cord...
To circumvent the subjective and qualitative problems of traditional tongue diagnosis, we present a novel computer aided tongue diagnosis system (CATDS). In this system, a standard acquisition device as well as a new color correction method is utilized to capture qualified tongue images. The system is constituted by five components: user interface module, acquisition module, tongue image database,...
This paper presents a new method for measuring ocular torsion using the optical flow. Iris image is cropped and transformed into rectangular image to make an orientation invariant image. Feature points were selected at iris region from a reference and a target image, and then shift of each feature was calculated using iterative Lucas-Kanade method. The feature points were selected according to the...
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