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We constructed an impedance spectroscopy measurement system based on frequency response analyzer. Using four-terminal method, we measured impedance spectroscopy of rabbit different tissues in vitro within 5 to 360 minutes after excision at the frequency range from 1Hz to 1MHz. According to the measurement results, we analyzed the changes of characteristic parameters (Ro, Rinfin, fc and alpha) of different...
The blood hematocrit is well recognized as the versatile index of various physiological conditions especially for anemia, polycythemia and dehydration. However, the conventional method of the hematocrit measurement was conducted with the direct blood sampling. In this study, based on the similar principle of the pulse oximetry, a simple principle of optical noninvasive hematocrit measurement method,...
In the nearest future a lot of post-operative treatment and health monitoring is going to be performed in people's homes instead of in hospital. The increasing number of elderly people in the developed countries and the need for more advanced medical treatment and equipment in conjunction with economical demands will force the development of more cost-effective solutions. The equipment used must be...
During liver resection and liver transplant, liver is damaged by ischemia-reperfusion injury. Until now, there is no approved method to measure or predict the extent of liver injury during the operation. This is the preliminary study to make the real time monitoring system by quantification of bioimpedance and ischemia-reperfusion injury in liver. Sprague-Dawley rats were subjected to different periods...
Various biochemical and tissue sensors utilize layered configurations to accurately measure the physical parameters (e.g. refractive index) of the suspension or tissue under investigation. The most sensitive techniques, like these based on well-known surface plasmon resonance (SPR) phenomenon, are usually limited to surface sensing at the infrared and light wavelength bands. We present a new type...
Electronic data transfer by capacitive and galvanic coupling through the human body has been proposed by research and industry as a novel but highly promising technology for ultra low power wireless body LANs. Investigation on the most challenging questions considering data communication becomes enabled with a highly versatile measurement system for frequencies in the range of 10kHz to 1MHz. The human...
Major function of the heart is to pump blood flow up to all tissues or organs in the body, and it is generally recognized that cardiac function under various diseased conditions are mainly represented by a relationship between blood flow and pressure inside of the heart. In this report, an original proposal of evaluation method on cardiac function is introduced through a simultaneous measurement of...
We have proposed a method for non-invasively measuring the temperature changes of water in a micro-region using near infrared (NIR) light. The goal of this study is to measure the temperature changes of biological cells or tissues. This method is on the basis of the phenomenon that the NIR absorption spectrum of water depends on temperature. First, in order to confirm whether a right irradiation for...
A new method to accurately measure the mechanical properties of individual muscles and tendons under active contraction is presented. An individual muscle is activated selectively to different intensities through electrical stimulation with adjustable amplitude, frequency, and pulse width. During the course of active contraction of the stimulated muscle, muscle fiber pennation angle, muscle fascicle...
A measuring device for use in measuring calorie consumption includes a pulse input unit which detects a first heart rate of the user at a first point in an exercise period and a second heart rate of the user at a second point of the exercise period other than the first point, the pulse input unit not detecting a third heart rate between the first and second heart rates; and a controller which receives...
Time synchronization is necessary to a wireless sensor network (WSN). Existing time synchronization methods are mostly designed for large scale ad hoc network and are not suitable for small star network like wireless physiological information sensor network (WPISN). In this article we present a simple and power-efficient time synchronization method designed specially for WPISN, reference on demand...
The left-ventricle ejection fraction is an important cardiac-efficiency measure that is regularly used in cardiology. Standard estimations are based on time-consuming geometrical analysis and modelling, which requires experienced cardiologists. Alternative methods are very invasive due to the need for cardiac catheterization. In this paper we present and study a minimally-invasive indicator dilution...
The best way to control the spread of severe acute respiratory syndrome (SARS) is measuring the body temperature precisely, therefore, it is very important to develop a set of high-precision infrared thermodetector for medicine. The ambient temperature signal and the object temperature signal were collected with two channel AD gates of thermopile infrared sensor unit. The values were calculated by...
The accurate estimation of cerebral metabolic rate of O2 (CMRO2) is still an unavailable but highly desired clinical tool. The addition of a further experimental variable to near infra-red spectroscopy (NIRS) allows more information to be gained than has previously been possible. A physiological model is presented here that can be used to estimate CMRO2 from measurements of oxy- and deoxy- haemoglobin...
Wearable technology has been used in various health-related fields to develop advanced monitoring solutions. However, the monitoring function alone cannot meet all the requirements of personal customizing machine-supported exercise that have biosignal-based controls. In this paper, we propose a new wearable unit design equipped with measurement and control functions to support the personal customization...
Both patch clamp and laser scanning confocal microscopy (LSCM) was applied to appraise the Anisodamine's cardioprotective effects quantitatively and its mechanism were studied. MTT measurement was observed cell viability and Fluo-3/AM was utilized for real-time free calcium with LSCM; ICa,L exposed to Anisodamine was measured by whole-cell patch clamp recording technique. Our study observed that KCL-triggered...
Coronary artery disease (CAD) is a major cause of mortality in the western world. Although progress has been made in recent years for the noninvasive diagnosis of CAD, a widely available, inexpensive and effective diagnostic solution remains elusive. We have developed a novel ultrasound-based technology to detect and analyze the myocardial vibrations associated with diastolic murmurs produced by CAD...
Alternative site capillary blood sampling may be a useful way to reduce pain during skin puncture. The present study made quantitative measurement of pain and blood volume for both finger and arm sampling in 58 normal female subjects. Visual pain measures resulted in 1/5~1/3 pain scores for arm relative to finger sampling. Deeper puncture thru skin on arm caused more pain to some degree. 399/464 samples...
The clinical management of skeletal trauma and disease relies on radiographic imaging to infer bone quality. However, bone strength does not necessarily correlate well with image intensity. There is a need for a safe and convenient way to measure bone strength in situ. This paper presents a new technique to directly measure bone strength in situ at a microlevel scale through a microelectromechanical...
Electromagnetic and heat-transfer equations were solved to investigate a radio frequency (RF) rectangular resonant cavity applicator. The possibility of heating a deep-seated tumor was demonstrated. A torso-shaped dielectric phantom was made. It has electrical constants resembling those of human muscle. Several L-type antennas were made and placed at appropriate locations to heat a deep region. Measured...
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