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Hyperpolarized 3He gas MRI has a serious potential for assessing pulmonary functions. Due to the fact that the non-equilibrium of the gas results in a steady depletion of the signal level over the course of the excitations, the signal-to-noise ratio (SNR) can be independent of the number of the data acquisitions under certain circumstances. This provides a unique opportunity for parallel MRI for gaining...
Visible evidence of spinal column damage is only apparent in 14% of the patients who receive spinal damage. We use a humidity sensor array. The humidity sensor (HDP-05) is arranged and attached to pre-assigned regions along the spinal column nerve of the actual patient. Applying pressure to the urinary bladder causes the patient to sweat. It is possible to determine which spinal column autonomic nerve...
Analysis of high density oligonucleotide arrays for resequencing requires methods which are highly robust and accurate. We introduce an alternative base calling method built upon ABACUS with the particular advantage of achieving a very low rate for false positive detection of heterozygotes
To investigate the effects of phosphene array irregularity in visual prostheses, a model of phosphenes' positional uncertainty was devised and two different image down-sampling schemes, adapting and non-adapting, were proposed. Based on a simulation system, visual acuity tests were given to four normally sighted subjects under seven degrees of array irregularity and the two down-sampling schemes....
Dielectrophoresis is a powerful tool for the manipulation of particles and biological cells. The magnitude and direction of the DEP force is determined by the comparative conductivity and permeability of the medium and the particle. Most previous work has focused on single frequency studies. In this paper, we present the work of two frequency dielectrophoresis effects on a linear electrode array....
A high-throughput GeneChipreg probe array platform was established. This system offers automated processing of 96 samples in the industry standard 96-well plate format. We demonstrate that this new technology can deliver the same performance as the standard cartridge probe arrays
A novel electronic tongue system had been developed recently in our labs, which was based on impedance measurements of a hybrid sensor array of different polymer films either conjugated conducting polymers (CPs) or rendered conductive polymers by the addition of carbon black (CB) or single wall carbon nanotubes (CNT). In this work, preliminary experiments were carried out on a series of measurements...
A cell-to-cell fusion technique using 3-D microelectrodes array microchip has been developed. It permits cell-to-cell fusion operation in large amount simultaneously. And it needs much lower voltage (alternating voltage and pulse voltage) than the conventional cell fusion techniques. An array of 16 (4times4) microelectrodes can be fabricated on a 1times1cm silicon wafer. And an experimental system,...
Oligonucleotide fingerprinting of rRNA genes (OFRG) is a method for identifying arrayed ribosomal RNA genes (rDNA) through a series of hybridization experiments with short oligonucleotide probes. Due to its low cost and high speed, it is an effective tool for analyzing microbial communities. OFRG relies on probe sets that can discriminate large collections of clones. Although the currently used probe...
Microarray image analysis, an important aspect of microarray technology, faces vast amount of data processing. At present, the speed of microarray image analysis is quite limited by excessive manual intervention. The geometric structure of microarray determines that, while being analyzed, microarray image should be collimated in the scanning vertical orientation. If rotation or tilt happens in microarray...
Methods for noninvasive imaging of electrical function of the heart seem to become a clinical standard procedure the next years. Thus, the overall procedure has to meet clinical requirements as easy and fast application. In this study we propose a new electrode array meeting clinical requirements such as easy to apply and compatibility with routine leads. Within body surface regions of high sensitivity,...
Cross-study validation and combined analysis of microarray data is critical in genomic analysis. With so much genetic expression data being produced by microarrays in the study of cancer, knowing the extent to which these studies agree can provide valuable insight. Researchers from Johns Hopkins University, Baltimore used Pearson correlation coefficient to develop a system for performing cross-study...
In this work, a new concept in high field RF head coil design for MRI applications is presented. An 8-element phased array head coil operating at 4T is designed based on a hybrid method combining reciprocity theorem and inverse method. Both circularly or linearly polarized head coils can be designed. A FDTD/MOM calculation method is used to model the phased array head coil and to accurately calculate...
The set of gene micro-arrays, which consists of two leukemia types, was used as a target to evaluate the efficiency of novel integrated data mining classification process. Discovering the most relevant subset of genes among few thousands of analyzed genes is necessary to get accurate disease classification. Dimensional complexity of the classification process was reduced by a filter based on mutual...
Identification of genetic markers is a crucial step in the diagnosis, prognosis, and treatment of disease. This paper focuses on the application of a supervised classification technique, support vector machines (SVM), to high dimensional microarrays for marker identification. A case study of renal cell carcinoma (RCC) is used here to demonstrate and test the ability of SVMs to identify real biological...
Spontaneous firing play an important role in development of neuronal network. Activity-dependent modification of synaptic efficacy is widely recognized as a cellular basis of learning, memory, and development plasticity. Little is known of the activity-dependent modification of the synchronized spontaneous firing of the hippocampal networks. Long-term recording of spontaneous activity in cultured...
The investigation of interactions between two kinds of monoclonal antibodies and SARS virus with a label-free protein array technique were presented in this paper. The performance consists of three parts: a surface modification for ligand immobilization/surface, a protein array fabrication with an integrated microfluidic system for patterning, packaging and liquid handling, and a protein array reader...
In spinal cord injured patients, the ranimation of dysfunctional limbs has been achieved with extrinsic stimulation of skeletal muscle via surface, epimysial, and nerve cuff electrodes. However, these neural interfaces have a number of significant problems that are mitigated by the use of electrodes that are inserted directly into the nerves that innervate targeted muscles. These problems, and their...
Subretinal prosthesis is one kind of retinal prosthesis, which means that a microimplant based on MEMS technology is inserted in the subretinal space to stimulate the optic nerve and elicit an electrical-evoked response on the cortical region. The subretinal implant is made up of extraocular part and intraocular part. As an important part, the latter consists of accessorial setting and stimulation...
A new definition of mutual impedance for two coils used for simultaneous signal reception in MRI is introduced. The new mutual impedances are used to accurately quantify the mutual coupling effect between the two coils so that it can be removed from the measured terminal voltages. Using the new mutual impedances, a new decoupling method can be formulated to obtain the uncoupled voltages. Numerical...
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