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Summary form only given. The authors review the properties and functional characteristics of the H/sub 1/ receptor and postulate the nature of the ligand-receptor activation site using molecular modeling techniques. A model of the surface of the active site on the receptor was postulated and constructed using Sybyl software on a personal Iris workstation. The surface properties were inferred using...
The elastic mechanical properties of the cardiac myocyte membrane has been evaluated in terms of membrane stiffness and elastic moduli defined by area compressibility and shear strain. The method employed incorporates a membrane patch clamp system and micropipette aspiration, whereby negative pressure is applied to the membrane in the 10-60 mm Hg range. Calibration of the micromanipulation technique,...
A study was initiated to mechanically and histologically examine chemically processed patellar tendon allografts in sheep anterior cruciate ligament (ACL) repairs. One group of animals received frozen grafts that were processed with a chloroform/methanol solvent extraction technique, and a third sheep group received frozen tendons treated with a permeation enhanced extraction technique. Histologic...
The effect of exercise on optical properties of the limb is of interest when the optical properties can be related to changes at depth within the limb. Such information may suggest ways in which noninvasive optical methods can be used to monitor exercise. In the present study, a source-detector arrangement was connected to a computer for collection of data at approximately 7-s intervals during sitting,...
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