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Summary form only given. The authors review the properties and functional characteristics of the H/sub 1/ receptor and postulate the nature of the ligand-receptor activation site using molecular modeling techniques. A model of the surface of the active site on the receptor was postulated and constructed using Sybyl software on a personal Iris workstation. The surface properties were inferred using...
The elastic mechanical properties of the cardiac myocyte membrane has been evaluated in terms of membrane stiffness and elastic moduli defined by area compressibility and shear strain. The method employed incorporates a membrane patch clamp system and micropipette aspiration, whereby negative pressure is applied to the membrane in the 10-60 mm Hg range. Calibration of the micromanipulation technique,...
A study was initiated to mechanically and histologically examine chemically processed patellar tendon allografts in sheep anterior cruciate ligament (ACL) repairs. One group of animals received frozen grafts that were processed with a chloroform/methanol solvent extraction technique, and a third sheep group received frozen tendons treated with a permeation enhanced extraction technique. Histologic...
The authors derive a compartmental model for oxygen transport in vascular blood which is suitable for both steady and time-varying analysis, and which can be used with any kind of oxygen dissociation function. The derivation focuses on the establishment of expressions for the lumped convective term and the lumped oxygen dissociation function. Results of the simulation show that the value of the lumped...
A review of the empirical observations of ELF electric field effects on living tissue has led the authors to propose that effects occur through the action of the electric polarization forces which develop at the cell surface. Such an interaction mechanism predicts that the field effects should be associated with a time-development response as well as an actual deformation of the exposed cell. These...
The present study was designed to evaluate the effect of weak, environmental range, AC and DC magnetic fields on myosin light chain phosphorylation in a cell-free system. The exposure system applied AC (16 Hz, 20.9 mu T) and DC (0-200 mu T, vertically and/or horizontally) magnetic fields. The results suggest that all of the AC, DC, and combination AC/DC magnetic fields significantly (30-100%, p<...
Voltage gated ion channels activate in response to step changes in voltage but slowly inactivate even though the voltage is maintained. It has been proposed that part of the channel forms a ball tethered to a chain and inactivation occurs when this ball binds to a site blocking the pore of the channel. The authors derived the statistical properties of this model so that it can be quantitatively tested...
Stretch-activated ion channels (SACs) in myocytes isolated from neonatal rats were studied in cell-attached patches. Stretch was applied to cell-attached patches by suction (5-20 mm Hg) in the recording pipet. Stretch caused the triggering of action potentials that were recorded in cell-attached patches as biphasic action currents (ACs). The significance of a temporal correlation between SAC open...
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