Inhaled corticosteroid is a popular treatment for chronic respiratory diseases. Its side effects include decreased bone mineral density and osteoporosis. The aim of this study is to investigate the association of inhaled corticosteroids and fracture. The data of the patients who were 20 years old or older visiting healthcare centers (outpatients or inpatients) and had been prescribed with inhale corticosteroids within 2002–2010 were retrieved from the National Health Insurance Research Database (NHIRD) for this investigation. Patients diagnosed with hip fracture or vertebrate fractures before using inhaled corticosteroid were excluded. A Total of 11645 patients receiving inhaled corticosteroid therapy were included in this study; among them, 1134 (9.7%) with either hip fracture or vertebrate fracture were observed. The average cumulated inhaled corticosteroid for patients with fracture (230.14±442.76 mg) was significantly higher (p<0.001) than those without fracture (171.97±318.13 mg). Based on the analytical results, it was observed that long-term use of inhaled corticosteroids may induce osteoporosis and exhibit higher incidence of hip or vertebrate fractures.